Cargando…

Comparison of Repeated Doses of Ivermectin Versus Ivermectin Plus Albendazole for the Treatment of Onchocerciasis: A Randomized, Open-label, Clinical Trial

BACKGROUND: Improved treatment for onchocerciasis is needed to accelerate onchocerciasis elimination in Africa. Aiming to better exploit registered drugs, this study was undertaken to determine whether annual or semiannual treatment with ivermectin (IVM; 200 µg/kg) plus albendazole (ALB; 800 mg sing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Batsa Debrah, Linda, Klarmann-Schulz, Ute, Osei-Mensah, Jubin, Dubben, Bettina, Fischer, Kerstin, Mubarik, Yusif, Ayisi-Boateng, Nana Kwame, Ricchiuto, Arcangelo, Fimmers, Rolf, Konadu, Peter, Nadal, Jennifer, Gruetzmacher, Barbara, Weil, Gary, Kazura, James W, King, Christopher L, Debrah, Alexander Y, Hoerauf, Achim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Articles and Commentaries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428389/ https://www.ncbi.nlm.nih.gov/pubmed/31536624 http://dx.doi.org/10.1093/cid/ciz889

Ejemplares similares

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial
por: Klarmann-Schulz, Ute, et al.
Publicado: (2017)

Morbidity management and surveillance of lymphatic filariasis disease and acute dermatolymphangioadenitis attacks using a mobile phone-based tool by community health volunteers in Ghana
por: Debrah, Linda Batsa, et al.
Publicado: (2020)

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial
por: Debrah, Alexander Yaw, et al.
Publicado: (2015)

Immunoepidemiological Profiling of Onchocerciasis Patients Reveals Associations with Microfilaria Loads and Ivermectin Intake on Both Individual and Community Levels
por: Arndts, Kathrin, et al.
Publicado: (2014)

A randomized, open-label study of the tolerability and efficacy of one or three daily doses of ivermectin plus diethylcarbamazine and albendazole (IDA) versus one dose of ivermectin plus albendazole (IA) for treatment of onchocerciasis
por: Opoku, Nicholas O., et al.
Publicado: (2023)

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals
por: Arndts, Kathrin, et al.
Publicado: (2015)

Assessment of microfilarial loads in the skin of onchocerciasis patients after treatment with different regimens of doxycycline plus ivermectin
por: Debrah, Alexander Yaw, et al.
Publicado: (2006)

Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment
por: Ritter, Manuel, et al.
Publicado: (2019)

Histopathological evaluation of Onchocerca volvulus nodules by microscopy and by digital image analysis for the study of macrofilaricidal drug efficacy
por: Fischer, Kerstin, et al.
Publicado: (2023)

Potential Value of Triple Drug Therapy with Ivermectin, Diethylcarbamazine, and Albendazole (IDA) to Accelerate Elimination of Lymphatic Filariasis and Onchocerciasis in Africa
por: Fischer, Peter U., et al.
Publicado: (2017)

Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti
por: Debrah, Linda Batsa, et al.
Publicado: (2017)

Whole blood transcriptome analysis in onchocerciasis
por: Lagatie, Ole, et al.
Publicado: (2022)

Elimination of African Onchocerciasis: Modeling the Impact of Increasing the Frequency of Ivermectin Mass Treatment
por: Coffeng, Luc E., et al.
Publicado: (2014)

Step towards elimination of Wuchereria bancrofti in Southwest Tanzania 10 years after mass drug administration with Albendazole and Ivermectin
por: Mnkai, Jonathan, et al.
Publicado: (2022)

Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection
por: Henriquez‐Camacho, Cesar, et al.
Publicado: (2016)

Occurrence of Lymphatic Filariasis infection after 15 years of mass drug administration in two hotspot districts in the Upper East Region of Ghana
por: Adu Mensah, Derrick, et al.
Publicado: (2022)

Evaluation of Lymphatic Filariasis and Onchocerciasis in Three Senegalese Districts Treated for Onchocerciasis with Ivermectin
por: Wilson, Nana O., et al.
Publicado: (2016)

Adherence to ivermectin is more associated with perceptions of community directed treatment with ivermectin organization than with onchocerciasis beliefs
por: Dissak-Delon, Fanny Nadia, et al.
Publicado: (2017)

Uncertainty Surrounding Projections of the Long-Term Impact of Ivermectin Treatment on Human Onchocerciasis
por: Turner, Hugo C., et al.
Publicado: (2013)

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
por: Hoerauf, Achim, et al.
Publicado: (2007)

Detection of Gastrointestinal Nematode Populations Resistant to Albendazole and Ivermectin in Sheep
por: Mondragón-Ancelmo, Jaime, et al.
Publicado: (2019)

Would ivermectin for malaria control be beneficial in onchocerciasis-endemic regions?
por: Siewe Fodjo, Joseph Nelson, et al.
Publicado: (2019)

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
por: Hoerauf, Achim, et al.
Publicado: (2008)

A qPCR to quantify Wolbachia from few Onchocerca volvulus microfilariae as a surrogate for adult worm histology in clinical trials of antiwolbachial drugs
por: Schlabe, Stefan, et al.
Publicado: (2022)

Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and efficacy study of albendazole with ivermectin compared to treatment of single infection with bancroftian filariasis
por: Makunde, William H, et al.
Publicado: (2003)

Efficacy of High-Dose Albendazole with Ivermectin for Treating Imported Loiasis, Italy
por: Gobbi, Federico, et al.
Publicado: (2019)

Compliance with eight years of annual ivermectin treatment of onchocerciasis in Cameroon and Nigeria
por: Brieger, William R, et al.
Publicado: (2011)

The Efficacy of Doxycycline Treatment on Mansonella perstans Infection: An Open-Label, Randomized Trial in Ghana
por: Batsa Debrah, Linda, et al.
Publicado: (2019)

Impact of Annual versus Semiannual Mass Drug Administration with Ivermectin and Albendazole on Helminth Infections in Southeastern Liberia
por: Eneanya, Obiora A., et al.
Publicado: (2022)

The impact of ivermectin on onchocerciasis in villages co-endemic for lymphatic filariasis in an area of onchocerciasis recrudescence in Burkina Faso
por: Nikièma, Achille S., et al.
Publicado: (2021)

Prevalence of Lymphatic Filariasis and Treatment Effectiveness of Albendazole/ Ivermectin in Individuals with HIV Co-infection in Southwest-Tanzania
por: Kroidl, Inge, et al.
Publicado: (2016)

Reduced Type 2 Innate Lymphocyte Cell Frequencies in Patent Wuchereria bancrofti-Infected Individuals
por: Tamadaho, Ruth S. E., et al.
Publicado: (2023)

Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole
por: Speich, Benjamin, et al.
Publicado: (2016)

Impact of ivermectin on onchocerciasis transmission: assessing the empirical evidence that repeated ivermectin mass treatments may lead to elimination/eradication in West-Africa
por: Borsboom, Gerard JJM, et al.
Publicado: (2003)

Triple Co-Administration of Ivermectin, Albendazole and Praziquantel in Zanzibar: A Safety Study
por: Mohammed, Khalfan A., et al.
Publicado: (2008)

Persistence of onchocerciasis in villages in Enugu and Ogun states in Nigeria following many rounds of mass distribution of ivermectin
por: Ekpo, Uwem F., et al.
Publicado: (2022)

The Cost of Annual versus Biannual Community-Directed Treatment of Onchocerciasis with Ivermectin: Ghana as a Case Study
por: Turner, Hugo C., et al.
Publicado: (2013)

Impact of long-term treatment of onchocerciasis with ivermectin in Ecuador: potential for elimination of infection
por: Vieira, Juan Carlos, et al.
Publicado: (2007)

Primary motives for demand of ivermectin drug in mass distribution programmes to control onchocerciasis
por: Abanobi, Okwuoma, et al.
Publicado: (2011)

Interruption of Infection Transmission in the Onchocerciasis Focus of Ecuador Leading to the Cessation of Ivermectin Distribution
por: Lovato, Raquel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_35859lmcv3v330e5pr3ns9ig15