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Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort

BACKGROUND: Campylobacter infection is associated with impaired growth of children, even in the absence of symptoms. To examine the underlying mechanisms, we evaluated associations between Campylobacter infection, linear growth, and fecal microbial community features in a prospective birth cohort of...

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Autores principales: Rouhani, Saba, Griffin, Nicholas W, Yori, Pablo Peñataro, Olortegui, Maribel Paredes, Siguas Salas, Mery, Rengifo Trigoso, Dixner, Moulton, Lawrence H, Houpt, Eric R, Barratt, Michael J, Kosek, Margaret N, Gordon, Jeffrey I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428392/
https://www.ncbi.nlm.nih.gov/pubmed/31773126
http://dx.doi.org/10.1093/cid/ciz906
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author Rouhani, Saba
Griffin, Nicholas W
Yori, Pablo Peñataro
Olortegui, Maribel Paredes
Siguas Salas, Mery
Rengifo Trigoso, Dixner
Moulton, Lawrence H
Houpt, Eric R
Barratt, Michael J
Kosek, Margaret N
Gordon, Jeffrey I
author_facet Rouhani, Saba
Griffin, Nicholas W
Yori, Pablo Peñataro
Olortegui, Maribel Paredes
Siguas Salas, Mery
Rengifo Trigoso, Dixner
Moulton, Lawrence H
Houpt, Eric R
Barratt, Michael J
Kosek, Margaret N
Gordon, Jeffrey I
author_sort Rouhani, Saba
collection PubMed
description BACKGROUND: Campylobacter infection is associated with impaired growth of children, even in the absence of symptoms. To examine the underlying mechanisms, we evaluated associations between Campylobacter infection, linear growth, and fecal microbial community features in a prospective birth cohort of 271 children with a high burden of diarrhea and stunting in the Amazonian lowlands of Peru. METHODS: Campylobacter was identified using a broadly reactive, genus-specific enzyme-linked immunosorbent assay. 16S rRNA-based analyses were used to identify bacterial taxa in fecal samples at ages 6, 12, 18, and 24 months (N = 928). Associations between infection, growth, and gut microbial community composition were investigated using multiple linear regression adjusting for within-child correlations, age, and breastfeeding. Indicator species analyses identified taxa specifically associated with Campylobacter burden. RESULTS: Ninety-three percent (251) of children had Campylobacter present in asymptomatic fecal samples during the follow-up period. A 10% increase in the proportion of stools infected was associated with mean reductions of 0.02 length-for-age z scores (LAZ) at 3, 6, and 9 months thereafter (P < .01). We identified 13 bacterial taxa indicative of cumulative Campylobacter burden and 14 taxa significantly associated with high or low burden of enteroaggregative Escherichia coli, norovirus, or Giardia. CONCLUSIONS: Campylobacter infection is common in this cohort and associated with changes in microbial community composition. These results support the notion that disruptions to the fecal microbiota may help explain the observed effects of asymptomatic infections on growth in early life.
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spelling pubmed-74283922020-08-19 Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort Rouhani, Saba Griffin, Nicholas W Yori, Pablo Peñataro Olortegui, Maribel Paredes Siguas Salas, Mery Rengifo Trigoso, Dixner Moulton, Lawrence H Houpt, Eric R Barratt, Michael J Kosek, Margaret N Gordon, Jeffrey I Clin Infect Dis Articles and Commentaries BACKGROUND: Campylobacter infection is associated with impaired growth of children, even in the absence of symptoms. To examine the underlying mechanisms, we evaluated associations between Campylobacter infection, linear growth, and fecal microbial community features in a prospective birth cohort of 271 children with a high burden of diarrhea and stunting in the Amazonian lowlands of Peru. METHODS: Campylobacter was identified using a broadly reactive, genus-specific enzyme-linked immunosorbent assay. 16S rRNA-based analyses were used to identify bacterial taxa in fecal samples at ages 6, 12, 18, and 24 months (N = 928). Associations between infection, growth, and gut microbial community composition were investigated using multiple linear regression adjusting for within-child correlations, age, and breastfeeding. Indicator species analyses identified taxa specifically associated with Campylobacter burden. RESULTS: Ninety-three percent (251) of children had Campylobacter present in asymptomatic fecal samples during the follow-up period. A 10% increase in the proportion of stools infected was associated with mean reductions of 0.02 length-for-age z scores (LAZ) at 3, 6, and 9 months thereafter (P < .01). We identified 13 bacterial taxa indicative of cumulative Campylobacter burden and 14 taxa significantly associated with high or low burden of enteroaggregative Escherichia coli, norovirus, or Giardia. CONCLUSIONS: Campylobacter infection is common in this cohort and associated with changes in microbial community composition. These results support the notion that disruptions to the fecal microbiota may help explain the observed effects of asymptomatic infections on growth in early life. Oxford University Press 2020-08-15 2019-09-17 /pmc/articles/PMC7428392/ /pubmed/31773126 http://dx.doi.org/10.1093/cid/ciz906 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles and Commentaries
Rouhani, Saba
Griffin, Nicholas W
Yori, Pablo Peñataro
Olortegui, Maribel Paredes
Siguas Salas, Mery
Rengifo Trigoso, Dixner
Moulton, Lawrence H
Houpt, Eric R
Barratt, Michael J
Kosek, Margaret N
Gordon, Jeffrey I
Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort
title Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort
title_full Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort
title_fullStr Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort
title_full_unstemmed Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort
title_short Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort
title_sort gut microbiota features associated with campylobacter burden and postnatal linear growth deficits in a peruvian birth cohort
topic Articles and Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428392/
https://www.ncbi.nlm.nih.gov/pubmed/31773126
http://dx.doi.org/10.1093/cid/ciz906
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