Cargando…

Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom

In 2018 prion disease was detected in camels at an abattoir in Algeria for the first time. The emergence of prion disease in this species made it prudent to assess the probability of entry of the pathogen into the United Kingdom (UK) from this region. Potentially contaminated products were identifie...

Descripción completa

Detalles Bibliográficos
Autores principales: Horigan, Verity, Gale, Paul, Adkin, Amie, Konold, Timm, Cassar, Claire, Spiropoulos, John, Kelly, Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428426/
https://www.ncbi.nlm.nih.gov/pubmed/32837979
http://dx.doi.org/10.1016/j.mran.2020.100134
_version_ 1783571070228365312
author Horigan, Verity
Gale, Paul
Adkin, Amie
Konold, Timm
Cassar, Claire
Spiropoulos, John
Kelly, Louise
author_facet Horigan, Verity
Gale, Paul
Adkin, Amie
Konold, Timm
Cassar, Claire
Spiropoulos, John
Kelly, Louise
author_sort Horigan, Verity
collection PubMed
description In 2018 prion disease was detected in camels at an abattoir in Algeria for the first time. The emergence of prion disease in this species made it prudent to assess the probability of entry of the pathogen into the United Kingdom (UK) from this region. Potentially contaminated products were identified as evidenced by other prion diseases. The aggregated probability of entry of the pathogen was estimated as very high and high for legal milk and cheese imports respectively and very high, high and high for illegal meat, milk and cheese products respectively. This aggregated probability represents a qualitative assessment of the probability of one or more entry events per year into the UK; it gives no indication of the number of entry events per year. The uncertainty associated with these estimates was high due to the unknown variation in prevalence of infection in camels and an uncertain number and type of illegal products entering the UK. Potential public health implications of this pathogen are unknown although there is currently no evidence of zoonotic transmission of prion diseases other than bovine spongiform encephalopathy to humans.
format Online
Article
Text
id pubmed-7428426
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Published by Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-74284262020-08-16 Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom Horigan, Verity Gale, Paul Adkin, Amie Konold, Timm Cassar, Claire Spiropoulos, John Kelly, Louise Microb Risk Anal Article In 2018 prion disease was detected in camels at an abattoir in Algeria for the first time. The emergence of prion disease in this species made it prudent to assess the probability of entry of the pathogen into the United Kingdom (UK) from this region. Potentially contaminated products were identified as evidenced by other prion diseases. The aggregated probability of entry of the pathogen was estimated as very high and high for legal milk and cheese imports respectively and very high, high and high for illegal meat, milk and cheese products respectively. This aggregated probability represents a qualitative assessment of the probability of one or more entry events per year into the UK; it gives no indication of the number of entry events per year. The uncertainty associated with these estimates was high due to the unknown variation in prevalence of infection in camels and an uncertain number and type of illegal products entering the UK. Potential public health implications of this pathogen are unknown although there is currently no evidence of zoonotic transmission of prion diseases other than bovine spongiform encephalopathy to humans. Published by Elsevier B.V. 2020-12 2020-08-15 /pmc/articles/PMC7428426/ /pubmed/32837979 http://dx.doi.org/10.1016/j.mran.2020.100134 Text en Crown Copyright © 2020 Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Horigan, Verity
Gale, Paul
Adkin, Amie
Konold, Timm
Cassar, Claire
Spiropoulos, John
Kelly, Louise
Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom
title Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom
title_full Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom
title_fullStr Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom
title_full_unstemmed Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom
title_short Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom
title_sort assessing the aggregated probability of entry of a novel prion disease agent into the united kingdom
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428426/
https://www.ncbi.nlm.nih.gov/pubmed/32837979
http://dx.doi.org/10.1016/j.mran.2020.100134
work_keys_str_mv AT horiganverity assessingtheaggregatedprobabilityofentryofanovelpriondiseaseagentintotheunitedkingdom
AT galepaul assessingtheaggregatedprobabilityofentryofanovelpriondiseaseagentintotheunitedkingdom
AT adkinamie assessingtheaggregatedprobabilityofentryofanovelpriondiseaseagentintotheunitedkingdom
AT konoldtimm assessingtheaggregatedprobabilityofentryofanovelpriondiseaseagentintotheunitedkingdom
AT cassarclaire assessingtheaggregatedprobabilityofentryofanovelpriondiseaseagentintotheunitedkingdom
AT spiropoulosjohn assessingtheaggregatedprobabilityofentryofanovelpriondiseaseagentintotheunitedkingdom
AT kellylouise assessingtheaggregatedprobabilityofentryofanovelpriondiseaseagentintotheunitedkingdom