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Gepants for abortive treatment of migraine: A network meta‐analysis

OBJECTIVES: To evaluate and compare the efficacy and safety of gepants for abortive treatment of migraine by network meta‐analysis. MATERIALS & METHODS: Publications, which were randomized controlled trials (RCTs) about gepants for abortive treatment of migraine, were acquired from Pubmed and Co...

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Autores principales: Hong, Peiwei, Tan, Tianlin, Liu, Yao, Xiao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428487/
https://www.ncbi.nlm.nih.gov/pubmed/32525262
http://dx.doi.org/10.1002/brb3.1701
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author Hong, Peiwei
Tan, Tianlin
Liu, Yao
Xiao, Jing
author_facet Hong, Peiwei
Tan, Tianlin
Liu, Yao
Xiao, Jing
author_sort Hong, Peiwei
collection PubMed
description OBJECTIVES: To evaluate and compare the efficacy and safety of gepants for abortive treatment of migraine by network meta‐analysis. MATERIALS & METHODS: Publications, which were randomized controlled trials (RCTs) about gepants for abortive treatment of migraine, were acquired from Pubmed and Cochrane Library. The literatures screening and quality assessment followed the Cochrane handbook. Review manager 5.3 and Addis v1.16.8 were utilized for data analyzing. RESULTS: Totally, 15 RCTs were included in the network meta‐analysis. The trials enrolled were with high quality. There are 7 treatments were analyzed: BI 44370 TA, MK‐3207, olcegepant, rimegepant, telcagepant, ubrogepant, and placebo. Of these trials, 11,118 patients and 10,917 patients were assigned to one of 7 treatments randomly for efficacy assessment and safety assessment, respectively. In meta‐analysis of direct comparisons, all gepants were superior to placebo in achieving pain freedom 2 hr postdose and only rimegepant and telcagepant were higher than placebo in incidence of any adverse events. In network meta‐analysis, the rank best 3 drugs were olcegepant, BI 44370 TA, and MK‐3207 for efficacy outcomes. And the rank best 3 drugs were BI 44370 TA, placebo, and ubrogepant for safety outcomes. CONCLUSION: Gepants were effective for abortive treatment of migraine. The most effective treatment of gepants for migraine might be olcegepant which were administrated transvenously. And all of gepants were safe for migraine treatment with single dose.
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spelling pubmed-74284872020-08-17 Gepants for abortive treatment of migraine: A network meta‐analysis Hong, Peiwei Tan, Tianlin Liu, Yao Xiao, Jing Brain Behav Original Research OBJECTIVES: To evaluate and compare the efficacy and safety of gepants for abortive treatment of migraine by network meta‐analysis. MATERIALS & METHODS: Publications, which were randomized controlled trials (RCTs) about gepants for abortive treatment of migraine, were acquired from Pubmed and Cochrane Library. The literatures screening and quality assessment followed the Cochrane handbook. Review manager 5.3 and Addis v1.16.8 were utilized for data analyzing. RESULTS: Totally, 15 RCTs were included in the network meta‐analysis. The trials enrolled were with high quality. There are 7 treatments were analyzed: BI 44370 TA, MK‐3207, olcegepant, rimegepant, telcagepant, ubrogepant, and placebo. Of these trials, 11,118 patients and 10,917 patients were assigned to one of 7 treatments randomly for efficacy assessment and safety assessment, respectively. In meta‐analysis of direct comparisons, all gepants were superior to placebo in achieving pain freedom 2 hr postdose and only rimegepant and telcagepant were higher than placebo in incidence of any adverse events. In network meta‐analysis, the rank best 3 drugs were olcegepant, BI 44370 TA, and MK‐3207 for efficacy outcomes. And the rank best 3 drugs were BI 44370 TA, placebo, and ubrogepant for safety outcomes. CONCLUSION: Gepants were effective for abortive treatment of migraine. The most effective treatment of gepants for migraine might be olcegepant which were administrated transvenously. And all of gepants were safe for migraine treatment with single dose. John Wiley and Sons Inc. 2020-06-11 /pmc/articles/PMC7428487/ /pubmed/32525262 http://dx.doi.org/10.1002/brb3.1701 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Hong, Peiwei
Tan, Tianlin
Liu, Yao
Xiao, Jing
Gepants for abortive treatment of migraine: A network meta‐analysis
title Gepants for abortive treatment of migraine: A network meta‐analysis
title_full Gepants for abortive treatment of migraine: A network meta‐analysis
title_fullStr Gepants for abortive treatment of migraine: A network meta‐analysis
title_full_unstemmed Gepants for abortive treatment of migraine: A network meta‐analysis
title_short Gepants for abortive treatment of migraine: A network meta‐analysis
title_sort gepants for abortive treatment of migraine: a network meta‐analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428487/
https://www.ncbi.nlm.nih.gov/pubmed/32525262
http://dx.doi.org/10.1002/brb3.1701
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