Cargando…

B7‐33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction–Related Adverse Cardiac Remodeling in Mice

BACKGROUND: Human relaxin‐2 is a peptide hormone capable of pleiotropic effects in several organ systems. Its recombinant formulation (serelaxin) has been demonstrated to reduce infarct size and prevent excessive scar formation in animal models of cardiac ischemia‐reperfusion injury. B7‐33, a synthe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Devarakonda, Teja, Mauro, Adolfo G., Guzman, Geronimo, Hovsepian, Sahak, Cain, Chad, Das, Anindita, Praveen, Praveen, Hossain, Mohammed Akhter, Salloum, Fadi N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428518/ https://www.ncbi.nlm.nih.gov/pubmed/32295457 http://dx.doi.org/10.1161/JAHA.119.015748

Ejemplares similares

Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction
por: Devarakonda, Teja, et al.
Publicado: (2021)

Remote Ischemic Pre-Conditioning Attenuates Adverse Cardiac Remodeling and Mortality Following Doxorubicin Administration in Mice
por: Gertz, Zachary M., et al.
Publicado: (2019)

Chronic treatment with serelaxin mitigates adverse remodeling in a murine model of ischemic heart failure and modulates bioactive sphingolipid signaling
por: Devarakonda, Teja, et al.
Publicado: (2022)

Further Developments towards a Minimal Potent Derivative of Human Relaxin-2
por: Handley, Thomas N. G., et al.
Publicado: (2023)

A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity
por: Praveen, Praveen, et al.
Publicado: (2023)

Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists
por: Lee, Han Siean, et al.
Publicado: (2020)

Characterizing relaxin receptor expression and exploring relaxin’s effect on tissue remodeling/fibrosis in the human bladder
por: Diaz, Edward C., et al.
Publicado: (2020)

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin
por: Bruell, Shoni, et al.
Publicado: (2017)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
por: Kocan, Martina, et al.
Publicado: (2017)

C-Terminus of the B-Chain of Relaxin-3 Is Important for Receptor Activity
por: Shabanpoor, Fazel, et al.
Publicado: (2013)

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290
por: Huang, Zaohua, et al.
Publicado: (2015)

Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design
por: D'Ercole, Annunziata, et al.
Publicado: (2022)

Relaxin'
Publicado: (1983)

Relaxin
por: DeCherney, Alan H.
Publicado: (1982)

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
por: Hossain, Mohammed Akhter, et al.
Publicado: (2016)

Development of a selective agonist for relaxin family peptide receptor 3
por: Wei, Dian, et al.
Publicado: (2017)

Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2
por: Esteban-Lopez, Maria, et al.
Publicado: (2022)

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3
por: Bathgate, Ross A. D., et al.
Publicado: (2013)

Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling
por: Formigli, Lucia, et al.
Publicado: (2007)

Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
por: Jung, Bok Ki, et al.
Publicado: (2017)

Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling
por: Martin, Brian, et al.
Publicado: (2019)

Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds
por: Lee, Han Siean, et al.
Publicado: (2020)

Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction
por: Ng, Hooi Hooi, et al.
Publicado: (2021)

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization
por: Chan, Linda J., et al.
Publicado: (2013)

Porcine Relaxin but Not Serelaxin Shows Residual Bioactivity after In Vitro Simulated Intestinal Digestion—Clues for the Development of New Relaxin Peptide Agonists Suitable for Oral Delivery
por: Pacini, Lorenzo, et al.
Publicado: (2022)

Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data
por: Abboud, Cynthia, et al.
Publicado: (2021)

Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine
por: Koo, Ada, et al.
Publicado: (2022)

Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation
por: Ma, Yibao, et al.
Publicado: (2020)

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
por: Sethi, Ashish, et al.
Publicado: (2016)

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis
por: McBride, Andrew, et al.
Publicado: (2017)

Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK
por: Filippone, Scott M., et al.
Publicado: (2017)

Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290
por: Kaftanovskaya, Elena M., et al.
Publicado: (2017)

The effect of relaxin on the musculoskeletal system
por: Dehghan, F, et al.
Publicado: (2014)

Deciphering Non-coding RNAs in Cardiovascular Health and Disease
por: Das, Anindita, et al.
Publicado: (2018)

Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
por: Yun, In Sik, et al.
Publicado: (2019)

Relaxin Affects Airway Remodeling Genes Expression through Various Signal Pathways Connected with Transcription Factors
por: Wieczfinska, Joanna, et al.
Publicado: (2022)

Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors
por: Tapia Cáceres, Felipe, et al.
Publicado: (2022)

Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4
por: Praveen, Praveen, et al.
Publicado: (2019)

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability
por: Nair, Vinojini B., et al.
Publicado: (2015)

High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4
por: Lin, Guang-yao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_288god50ahkhdkkg4s9uc35nu8