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Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth

BACKGROUND: Approximately 1 in 6 adolescents report regular binge alcohol consumption, and we hypothesize it affects heart growth during this period. METHODS AND RESULTS: Adolescent, genetically diverse, male Wistar rats were gavaged with water or ethanol once per day for 6 days. In vivo structure a...

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Autores principales: Ai, Lizhuo, Perez, Edith, Asimes, AnnaDorothea, Kampaengsri, Theerachat, Heroux, Maxime, Zlobin, Andrei, Hiske, Mark A., Chung, Charles S., Pak, Toni R., Kirk, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428579/
https://www.ncbi.nlm.nih.gov/pubmed/32319345
http://dx.doi.org/10.1161/JAHA.119.015611
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author Ai, Lizhuo
Perez, Edith
Asimes, AnnaDorothea
Kampaengsri, Theerachat
Heroux, Maxime
Zlobin, Andrei
Hiske, Mark A.
Chung, Charles S.
Pak, Toni R.
Kirk, Jonathan A.
author_facet Ai, Lizhuo
Perez, Edith
Asimes, AnnaDorothea
Kampaengsri, Theerachat
Heroux, Maxime
Zlobin, Andrei
Hiske, Mark A.
Chung, Charles S.
Pak, Toni R.
Kirk, Jonathan A.
author_sort Ai, Lizhuo
collection PubMed
description BACKGROUND: Approximately 1 in 6 adolescents report regular binge alcohol consumption, and we hypothesize it affects heart growth during this period. METHODS AND RESULTS: Adolescent, genetically diverse, male Wistar rats were gavaged with water or ethanol once per day for 6 days. In vivo structure and function were assessed before and after exposure. Binge alcohol exposure in adolescence significantly impaired normal cardiac growth but did not affect whole‐body growth during adolescence, therefore this pathology was specific to the heart. Binge rats also exhibited signs of accelerated pathological growth (concentric cellular hypertrophy and thickening of the myocardial wall), suggesting a global reorientation from physiologic to pathologic growth. Binge rats compensated for their smaller filling volumes by increasing systolic function and sympathetic stimulation. Consequently, binge alcohol exposure increased PKA (protein kinase A) phosphorylation of troponin I, inducing myofilament calcium desensitization. Binge alcohol also impaired in vivo relaxation and increased titin‐based cellular stiffness due to titin phosphorylation by PKCα (protein kinase C α). Mechanistically, alcohol inhibited extracellular signal‐related kinase activity, a nodal signaling kinase activating physiology hypertrophy. Thus, binge alcohol exposure depressed genes involved in growth. These cardiac structural alterations from binge alcohol exposure persisted through adolescence even after cessation of ethanol exposure. CONCLUSIONS: Alcohol negatively impacts function in the adult heart, but the adolescent heart is substantially more sensitive to its effects. This difference is likely because adolescent binge alcohol impedes the normal rapid physiological growth and reorients it towards pathological hypertrophy. Many adolescents regularly binge alcohol, and here we report a novel pathological consequence as well as mechanisms involved.
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spelling pubmed-74285792020-08-17 Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth Ai, Lizhuo Perez, Edith Asimes, AnnaDorothea Kampaengsri, Theerachat Heroux, Maxime Zlobin, Andrei Hiske, Mark A. Chung, Charles S. Pak, Toni R. Kirk, Jonathan A. J Am Heart Assoc Original Research BACKGROUND: Approximately 1 in 6 adolescents report regular binge alcohol consumption, and we hypothesize it affects heart growth during this period. METHODS AND RESULTS: Adolescent, genetically diverse, male Wistar rats were gavaged with water or ethanol once per day for 6 days. In vivo structure and function were assessed before and after exposure. Binge alcohol exposure in adolescence significantly impaired normal cardiac growth but did not affect whole‐body growth during adolescence, therefore this pathology was specific to the heart. Binge rats also exhibited signs of accelerated pathological growth (concentric cellular hypertrophy and thickening of the myocardial wall), suggesting a global reorientation from physiologic to pathologic growth. Binge rats compensated for their smaller filling volumes by increasing systolic function and sympathetic stimulation. Consequently, binge alcohol exposure increased PKA (protein kinase A) phosphorylation of troponin I, inducing myofilament calcium desensitization. Binge alcohol also impaired in vivo relaxation and increased titin‐based cellular stiffness due to titin phosphorylation by PKCα (protein kinase C α). Mechanistically, alcohol inhibited extracellular signal‐related kinase activity, a nodal signaling kinase activating physiology hypertrophy. Thus, binge alcohol exposure depressed genes involved in growth. These cardiac structural alterations from binge alcohol exposure persisted through adolescence even after cessation of ethanol exposure. CONCLUSIONS: Alcohol negatively impacts function in the adult heart, but the adolescent heart is substantially more sensitive to its effects. This difference is likely because adolescent binge alcohol impedes the normal rapid physiological growth and reorients it towards pathological hypertrophy. Many adolescents regularly binge alcohol, and here we report a novel pathological consequence as well as mechanisms involved. John Wiley and Sons Inc. 2020-04-22 /pmc/articles/PMC7428579/ /pubmed/32319345 http://dx.doi.org/10.1161/JAHA.119.015611 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Ai, Lizhuo
Perez, Edith
Asimes, AnnaDorothea
Kampaengsri, Theerachat
Heroux, Maxime
Zlobin, Andrei
Hiske, Mark A.
Chung, Charles S.
Pak, Toni R.
Kirk, Jonathan A.
Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth
title Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth
title_full Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth
title_fullStr Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth
title_full_unstemmed Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth
title_short Binge Alcohol Exposure in Adolescence Impairs Normal Heart Growth
title_sort binge alcohol exposure in adolescence impairs normal heart growth
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428579/
https://www.ncbi.nlm.nih.gov/pubmed/32319345
http://dx.doi.org/10.1161/JAHA.119.015611
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