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Updates on community acquired pneumonia management in the ICU

While the world is grappling with the consequences of a global pandemic related to SARS-CoV-2 causing severe pneumonia, available evidence points to bacterial infection with Streptococcus pneumoniae as the most common cause of severe community acquired pneumonia (SCAP). Rapid diagnostics and molecul...

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Autores principales: Nair, Girish B., Niederman, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428725/
https://www.ncbi.nlm.nih.gov/pubmed/32805298
http://dx.doi.org/10.1016/j.pharmthera.2020.107663
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author Nair, Girish B.
Niederman, Michael S.
author_facet Nair, Girish B.
Niederman, Michael S.
author_sort Nair, Girish B.
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description While the world is grappling with the consequences of a global pandemic related to SARS-CoV-2 causing severe pneumonia, available evidence points to bacterial infection with Streptococcus pneumoniae as the most common cause of severe community acquired pneumonia (SCAP). Rapid diagnostics and molecular testing have improved the identification of co-existent pathogens. However, mortality in patients admitted to ICU remains staggeringly high. The American Thoracic Society and Infectious Diseases Society of America have updated CAP guidelines to help streamline disease management. The common theme is use of timely, appropriate and adequate antibiotic coverage to decrease mortality and avoid drug resistance. Novel antibiotics have been studied for CAP and extend the choice of therapy, particularly for those who are intolerant of, or not responding to standard treatment, including those who harbor drug resistant pathogens. In this review, we focus on the risk factors, microbiology, site of care decisions and treatment of patients with SCAP.
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spelling pubmed-74287252020-08-17 Updates on community acquired pneumonia management in the ICU Nair, Girish B. Niederman, Michael S. Pharmacol Ther Article While the world is grappling with the consequences of a global pandemic related to SARS-CoV-2 causing severe pneumonia, available evidence points to bacterial infection with Streptococcus pneumoniae as the most common cause of severe community acquired pneumonia (SCAP). Rapid diagnostics and molecular testing have improved the identification of co-existent pathogens. However, mortality in patients admitted to ICU remains staggeringly high. The American Thoracic Society and Infectious Diseases Society of America have updated CAP guidelines to help streamline disease management. The common theme is use of timely, appropriate and adequate antibiotic coverage to decrease mortality and avoid drug resistance. Novel antibiotics have been studied for CAP and extend the choice of therapy, particularly for those who are intolerant of, or not responding to standard treatment, including those who harbor drug resistant pathogens. In this review, we focus on the risk factors, microbiology, site of care decisions and treatment of patients with SCAP. Elsevier Inc. 2021-01 2020-08-15 /pmc/articles/PMC7428725/ /pubmed/32805298 http://dx.doi.org/10.1016/j.pharmthera.2020.107663 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Nair, Girish B.
Niederman, Michael S.
Updates on community acquired pneumonia management in the ICU
title Updates on community acquired pneumonia management in the ICU
title_full Updates on community acquired pneumonia management in the ICU
title_fullStr Updates on community acquired pneumonia management in the ICU
title_full_unstemmed Updates on community acquired pneumonia management in the ICU
title_short Updates on community acquired pneumonia management in the ICU
title_sort updates on community acquired pneumonia management in the icu
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428725/
https://www.ncbi.nlm.nih.gov/pubmed/32805298
http://dx.doi.org/10.1016/j.pharmthera.2020.107663
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