Tetrodotoxin‐Sensitive Neuronal‐Type Na(+) Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation

BACKGROUND: Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca(2+)‐dependent nature of both of these pathologies, AF often responds to Na(+) channel blockers. We investigated how targeting interdependent N...

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Detalles Bibliográficos
Autores principales: Munger, Mark A., Olğar, Yusuf, Koleske, Megan L., Struckman, Heather L., Mandrioli, Jessica, Lou, Qing, Bonila, Ingrid, Kim, Kibum, Ramos Mondragon, Roberto, Priori, Silvia G., Volpe, Pompeo, Valdivia, Héctor H., Biskupiak, Joseph, Carnes, Cynthia A., Veeraraghavan, Rengasayee, Györke, Sándor, Radwański, Przemysław B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429002/
https://www.ncbi.nlm.nih.gov/pubmed/32468902
http://dx.doi.org/10.1161/JAHA.119.015119

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