Enhanced Generation of Induced Cardiomyocytes Using a Small‐Molecule Cocktail to Overcome Barriers to Cardiac Cellular Reprogramming

BACKGROUND: Given known inefficiencies in reprogramming of fibroblasts into mature induced cardiomyocytes (iCMs), we sought to identify small molecules that would overcome these barriers to cardiac cell transdifferentiation. METHODS AND RESULTS: We screened alternative combinations of compounds know...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Vivek P., Pinnamaneni, Jaya Pratap, Pugazenthi, Aarthi, Sanagasetti, Deepthi, Mathison, Megumi, Wang, Kai, Yang, Jianchang, Rosengart, Todd K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429035/
https://www.ncbi.nlm.nih.gov/pubmed/32500803
http://dx.doi.org/10.1161/JAHA.119.015686

Ejemplares similares

Ejemplares similares