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Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis

BACKGROUND: Aberrant activation of the NLRP3 (nucleotide‐binding oligomerization domain, leucine‐rich repeat–containing receptor family pyrin domain‐containing 3) inflammasome is thought to play a causative role in atherosclerosis. NLRP3 is kept in an inactive ubiquitinated state to avoid unwanted N...

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Detalles Bibliográficos
Autores principales:	Chen, Suwen, Wang, Yadong, Pan, Yamu, Liu, Yao, Zheng, Shuang, Ding, Ke, Mu, Kaiyu, Yuan, Ye, Li, Zhaoyang, Song, Hongxian, Jin, Ying, Fu, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429049/ https://www.ncbi.nlm.nih.gov/pubmed/32476536 http://dx.doi.org/10.1161/JAHA.119.015513

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