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Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study

BACKGROUND: Relatively little is known about the long‐term consequences of venous thromboembolism (VTE) on physical functioning. We compared long‐term frailty status, physical function, and quality of life among survivors of VTE with survivors of coronary heart disease (CHD) and stroke, and with tho...

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Autores principales: Lutsey, Pamela L., Windham, B. Gwen, Misialek, Jeffrey R., Cushman, Mary, Kucharska‐Newton, Anna, Basu, Saonli, Folsom, Aaron R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429054/
https://www.ncbi.nlm.nih.gov/pubmed/32476561
http://dx.doi.org/10.1161/JAHA.119.015656
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author Lutsey, Pamela L.
Windham, B. Gwen
Misialek, Jeffrey R.
Cushman, Mary
Kucharska‐Newton, Anna
Basu, Saonli
Folsom, Aaron R.
author_facet Lutsey, Pamela L.
Windham, B. Gwen
Misialek, Jeffrey R.
Cushman, Mary
Kucharska‐Newton, Anna
Basu, Saonli
Folsom, Aaron R.
author_sort Lutsey, Pamela L.
collection PubMed
description BACKGROUND: Relatively little is known about the long‐term consequences of venous thromboembolism (VTE) on physical functioning. We compared long‐term frailty status, physical function, and quality of life among survivors of VTE with survivors of coronary heart disease (CHD) and stroke, and with those without these diseases. METHODS AND RESULTS: Cases of VTE, CHD, and stroke were continuously identified since ARIC (Atherosclerosis Risk in Communities Study) recruitment during 1987 to 1989. Functional measures were objectively captured at ARIC clinic visits 5 (2011–2013) and 6 (2016–2017); quality of life was self‐reported. The 6161 participants at visit 5 were, on average, 75.7 (range, 66–90) years of age. By visit 5, 3.2% had had a VTE, 6.9% CHD, and 3.4% stroke. Compared with those without any of these conditions, VTE survivors were more likely to be frail (odds ratio [OR], 3.11; 95% CI, 1.80–5.36) and have low (<10) versus good scores on the Short Physical Performance Battery (OR, 3.59; 95% CI, 2.36–5.47). They also had slower gait speed, less endurance, and lower physical quality of life. VTE survivors were similar to coronary heart disease and stroke survivors on categorical frailty and outcomes on Short Physical Performance Battery assessment. When score on the Short Physical Performance Battery instrument was modeled continuously, VTE survivors performed better than stroke survivors but worse than CHD survivors. CONCLUSIONS: VTE survivors had triple the odds of frailty and poorer physical function than those without the vascular diseases considered. Their function was somewhat worse than that of CHD survivors, but better than stroke survivors. These findings suggest that VTE patients may benefit from additional efforts to improve postevent physical functioning.
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spelling pubmed-74290542020-08-18 Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study Lutsey, Pamela L. Windham, B. Gwen Misialek, Jeffrey R. Cushman, Mary Kucharska‐Newton, Anna Basu, Saonli Folsom, Aaron R. J Am Heart Assoc Original Research BACKGROUND: Relatively little is known about the long‐term consequences of venous thromboembolism (VTE) on physical functioning. We compared long‐term frailty status, physical function, and quality of life among survivors of VTE with survivors of coronary heart disease (CHD) and stroke, and with those without these diseases. METHODS AND RESULTS: Cases of VTE, CHD, and stroke were continuously identified since ARIC (Atherosclerosis Risk in Communities Study) recruitment during 1987 to 1989. Functional measures were objectively captured at ARIC clinic visits 5 (2011–2013) and 6 (2016–2017); quality of life was self‐reported. The 6161 participants at visit 5 were, on average, 75.7 (range, 66–90) years of age. By visit 5, 3.2% had had a VTE, 6.9% CHD, and 3.4% stroke. Compared with those without any of these conditions, VTE survivors were more likely to be frail (odds ratio [OR], 3.11; 95% CI, 1.80–5.36) and have low (<10) versus good scores on the Short Physical Performance Battery (OR, 3.59; 95% CI, 2.36–5.47). They also had slower gait speed, less endurance, and lower physical quality of life. VTE survivors were similar to coronary heart disease and stroke survivors on categorical frailty and outcomes on Short Physical Performance Battery assessment. When score on the Short Physical Performance Battery instrument was modeled continuously, VTE survivors performed better than stroke survivors but worse than CHD survivors. CONCLUSIONS: VTE survivors had triple the odds of frailty and poorer physical function than those without the vascular diseases considered. Their function was somewhat worse than that of CHD survivors, but better than stroke survivors. These findings suggest that VTE patients may benefit from additional efforts to improve postevent physical functioning. John Wiley and Sons Inc. 2020-06-01 /pmc/articles/PMC7429054/ /pubmed/32476561 http://dx.doi.org/10.1161/JAHA.119.015656 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Lutsey, Pamela L.
Windham, B. Gwen
Misialek, Jeffrey R.
Cushman, Mary
Kucharska‐Newton, Anna
Basu, Saonli
Folsom, Aaron R.
Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study
title Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study
title_full Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study
title_fullStr Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study
title_full_unstemmed Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study
title_short Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study
title_sort long‐term association of venous thromboembolism with frailty, physical functioning, and quality of life: the atherosclerosis risk in communities study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429054/
https://www.ncbi.nlm.nih.gov/pubmed/32476561
http://dx.doi.org/10.1161/JAHA.119.015656
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