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Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
OBJECTIVE: This study compared the effect of levetiracetam (LEV) as monotherapy to sodium valproate (VPA) as monotherapy on cognitive functions in patients with epilepsy. METHODS: This was a comparative prospective study on 50 patients with newly diagnosed epilepsy started on antiseizure medications...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429224/ https://www.ncbi.nlm.nih.gov/pubmed/32848400 http://dx.doi.org/10.2147/NDT.S256117 |
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author | El Sabaa, Ramy M Hamdi, Emad Hamdy, Nermin Aly Sarhan, Hatem A |
author_facet | El Sabaa, Ramy M Hamdi, Emad Hamdy, Nermin Aly Sarhan, Hatem A |
author_sort | El Sabaa, Ramy M |
collection | PubMed |
description | OBJECTIVE: This study compared the effect of levetiracetam (LEV) as monotherapy to sodium valproate (VPA) as monotherapy on cognitive functions in patients with epilepsy. METHODS: This was a comparative prospective study on 50 patients with newly diagnosed epilepsy started on antiseizure medications. Patients were selected from the neurology-outpatient clinics at Minia University Hospital, Minia, Egypt. They were divided into two groups: group treated with LEV and group treated with VPA. All patients were subjected to cognitive function assessment using reaction-time tests, trail-making tests, and Wisconsin card-sorting test before treatment and 3 months after treatment. RESULTS: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment. CONCLUSION: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment. |
format | Online Article Text |
id | pubmed-7429224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-74292242020-08-25 Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy El Sabaa, Ramy M Hamdi, Emad Hamdy, Nermin Aly Sarhan, Hatem A Neuropsychiatr Dis Treat Original Research OBJECTIVE: This study compared the effect of levetiracetam (LEV) as monotherapy to sodium valproate (VPA) as monotherapy on cognitive functions in patients with epilepsy. METHODS: This was a comparative prospective study on 50 patients with newly diagnosed epilepsy started on antiseizure medications. Patients were selected from the neurology-outpatient clinics at Minia University Hospital, Minia, Egypt. They were divided into two groups: group treated with LEV and group treated with VPA. All patients were subjected to cognitive function assessment using reaction-time tests, trail-making tests, and Wisconsin card-sorting test before treatment and 3 months after treatment. RESULTS: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment. CONCLUSION: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment. Dove 2020-08-11 /pmc/articles/PMC7429224/ /pubmed/32848400 http://dx.doi.org/10.2147/NDT.S256117 Text en © 2020 El Sabaa et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research El Sabaa, Ramy M Hamdi, Emad Hamdy, Nermin Aly Sarhan, Hatem A Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy |
title | Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy |
title_full | Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy |
title_fullStr | Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy |
title_full_unstemmed | Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy |
title_short | Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy |
title_sort | effects of levetiracetam compared to valproate on cognitive functions of patients with epilepsy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429224/ https://www.ncbi.nlm.nih.gov/pubmed/32848400 http://dx.doi.org/10.2147/NDT.S256117 |
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