GWAS Significance Thresholds for Deep Phenotyping Studies Can Depend Upon Minor Allele Frequencies and Sample Size

An important issue affecting Genome-Wide Association Studies (GWAS) with deep phenotyping (multiple correlated phenotypes) is determining the suitable family-wise significance threshold. Straightforward family-wise correction (Bonferroni) of p <0.05 for 4.3 million genotypes and 335 phenotypes wo...

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Detalles Bibliográficos
Autores principales: Asif, Huma, Alliey-Rodriguez, Ney, Keedy, Sarah, Tamminga, Carol A., Sweeney, John A, Pearlson, Godfrey, Clementz, Brett A., Keshavan, Matcheri S., Buckley, Peter, Liu, Chunyu, Neale, Benjamin, Gershon, Elliot S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429341/
https://www.ncbi.nlm.nih.gov/pubmed/32066829
http://dx.doi.org/10.1038/s41380-020-0670-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429341/
https://www.ncbi.nlm.nih.gov/pubmed/32066829
http://dx.doi.org/10.1038/s41380-020-0670-3

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