Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism

BACKGROUND: Distal arthrogryposis (DA) is a group of autosomal dominant skeletal muscle diseases characterized by congenital contractures of distal limb joints. The most common cause of DA is a mutation of the embryonic myosin heavy chain gene, MYH3. Human phenotypes of DA are divided into the weake...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Yiming, Kronert, William A., Hsu, Karen H., Huang, Alice, Sarsoza, Floyd, Bell, Kaylyn M., Suggs, Jennifer A., Swank, Douglas M., Bernstein, Sanford I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429702/
https://www.ncbi.nlm.nih.gov/pubmed/32799913
http://dx.doi.org/10.1186/s13395-020-00241-6

Ejemplares similares

Ejemplares similares