T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is the second most prevalent movement disorder characterized by up to 80% loss of dopamine (DA) neurons and accumulation of Lewy body deposits composed of α-synuclein (α-syn). Accumulation of α-syn is associated with microglial activation, leading to a pro-inflam...

Descripción completa

Detalles Bibliográficos
Autores principales: Subbarayan, Meena S., Hudson, Charles, Moss, Lauren D., Nash, Kevin R., Bickford, Paula C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429710/
https://www.ncbi.nlm.nih.gov/pubmed/32799878
http://dx.doi.org/10.1186/s12974-020-01911-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429710/
https://www.ncbi.nlm.nih.gov/pubmed/32799878
http://dx.doi.org/10.1186/s12974-020-01911-4

Ejemplares similares