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T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is the second most prevalent movement disorder characterized by up to 80% loss of dopamine (DA) neurons and accumulation of Lewy body deposits composed of α-synuclein (α-syn). Accumulation of α-syn is associated with microglial activation, leading to a pro-inflam...

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Detalles Bibliográficos
Autores principales:	Subbarayan, Meena S., Hudson, Charles, Moss, Lauren D., Nash, Kevin R., Bickford, Paula C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429710/ https://www.ncbi.nlm.nih.gov/pubmed/32799878 http://dx.doi.org/10.1186/s12974-020-01911-4

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