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Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease

BACKGROUND: Ischemic Moyamoya disease is one of the important causes of stroke, which leads to severe impairment in cognitive functions. This cognitive impairment occurs prior to stroke. However, the cognitive functions that are impaired and the mechanisms of these impairments have not been determin...

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Autores principales: Liu, Ziqi, He, Shihao, Xu, Zongsheng, Duan, Ran, Yuan, Li, Xiao, Chu, Yi, Zhe, Wang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429789/
https://www.ncbi.nlm.nih.gov/pubmed/32799829
http://dx.doi.org/10.1186/s12883-020-01876-0
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author Liu, Ziqi
He, Shihao
Xu, Zongsheng
Duan, Ran
Yuan, Li
Xiao, Chu
Yi, Zhe
Wang, Rong
author_facet Liu, Ziqi
He, Shihao
Xu, Zongsheng
Duan, Ran
Yuan, Li
Xiao, Chu
Yi, Zhe
Wang, Rong
author_sort Liu, Ziqi
collection PubMed
description BACKGROUND: Ischemic Moyamoya disease is one of the important causes of stroke, which leads to severe impairment in cognitive functions. This cognitive impairment occurs prior to stroke. However, the cognitive functions that are impaired and the mechanisms of these impairments have not been determined. METHODS: We analyzed 12 patients with Moyamoya disease and 12 controls. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scans. The diffusion tensor imaging (DTI) data was processed using Tract-Based Spatial Statistics (TBSS). Significantly different white matter areas were correlated with different cognitive functions. RESULTS: There were significant differences in intelligence and subtraction between the patients and controls (p < 0.05). The parameters of DTI such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) have different changes in anterior thalamic radiation, inferior fronto-occipital fasciculus (IFO), superior longitudinal fasciculus (SLF), uncinate fasciculus (UF), inferior longitudinal fasciculus, forceps minor, and other regions between the two groups. CONCLUSION: Left UF and IFO may be the key brain regions affecting arithmetic function, while bilateral IFO has an effect on intelligence. RD and AD may be better indicators for early prediction of chronic white matter damage than FA, while MD tends to have a comprehensive indirect change. There is cognitive impairment in ischemic MMD, which is closely related to white matter impairment. TRIAL REGISTRATION: Clinical Trial Registration, Unique identifier: ChiCTR1900023610. Registered 4 June 2019 – Prospective study registered.
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spelling pubmed-74297892020-08-18 Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease Liu, Ziqi He, Shihao Xu, Zongsheng Duan, Ran Yuan, Li Xiao, Chu Yi, Zhe Wang, Rong BMC Neurol Research Article BACKGROUND: Ischemic Moyamoya disease is one of the important causes of stroke, which leads to severe impairment in cognitive functions. This cognitive impairment occurs prior to stroke. However, the cognitive functions that are impaired and the mechanisms of these impairments have not been determined. METHODS: We analyzed 12 patients with Moyamoya disease and 12 controls. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scans. The diffusion tensor imaging (DTI) data was processed using Tract-Based Spatial Statistics (TBSS). Significantly different white matter areas were correlated with different cognitive functions. RESULTS: There were significant differences in intelligence and subtraction between the patients and controls (p < 0.05). The parameters of DTI such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) have different changes in anterior thalamic radiation, inferior fronto-occipital fasciculus (IFO), superior longitudinal fasciculus (SLF), uncinate fasciculus (UF), inferior longitudinal fasciculus, forceps minor, and other regions between the two groups. CONCLUSION: Left UF and IFO may be the key brain regions affecting arithmetic function, while bilateral IFO has an effect on intelligence. RD and AD may be better indicators for early prediction of chronic white matter damage than FA, while MD tends to have a comprehensive indirect change. There is cognitive impairment in ischemic MMD, which is closely related to white matter impairment. TRIAL REGISTRATION: Clinical Trial Registration, Unique identifier: ChiCTR1900023610. Registered 4 June 2019 – Prospective study registered. BioMed Central 2020-08-15 /pmc/articles/PMC7429789/ /pubmed/32799829 http://dx.doi.org/10.1186/s12883-020-01876-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Liu, Ziqi
He, Shihao
Xu, Zongsheng
Duan, Ran
Yuan, Li
Xiao, Chu
Yi, Zhe
Wang, Rong
Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease
title Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease
title_full Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease
title_fullStr Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease
title_full_unstemmed Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease
title_short Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease
title_sort association between white matter impairment and cognitive dysfunction in patients with ischemic moyamoya disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429789/
https://www.ncbi.nlm.nih.gov/pubmed/32799829
http://dx.doi.org/10.1186/s12883-020-01876-0
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