Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF

Induction of lethal autophagy has become a strategy to eliminate glioma cells, but it remains elusive whether autophagy contributes to cell death via causing mitochondria damage and nuclear translocation of apoptosis inducing factor (AIF). In this study, we find that silibinin induces AIF translocat...

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Detalles Bibliográficos
Autores principales: Wang, Chongcheng, He, Chuan, Lu, Shan, Wang, Xuanzhong, Wang, Lei, Liang, Shipeng, Wang, Xinyu, Piao, Meihua, Cui, Jiayue, Chi, Guangfan, Ge, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429844/
https://www.ncbi.nlm.nih.gov/pubmed/32801360
http://dx.doi.org/10.1038/s41419-020-02866-3

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