The SCF(Skp2) ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

TRAIL-R2 (DR5) is a clinically-relevant therapeutic target and a key target for immune effector cells. Herein, we identify a novel interaction between TRAIL-R2 and the Skp1-Cullin-1-F-box (SCF) Cullin-Ring E3 Ubiquitin Ligase complex containing Skp2 (SCF(Skp2)). We find that SCF(Skp2) can interact w...

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Detalles Bibliográficos
Autores principales: Roberts, Jamie Z., Holohan, Caitriona, Sessler, Tamas, Fox, Jennifer, Crawford, Nyree, Riley, Joel S., Khawaja, Hajrah, Majkut, Joanna, Evergren, Emma, Humphreys, Luke M., Ferris, Jennifer, Higgins, Catherine, Espona-Fiedler, Margarita, Moynagh, Paul, McDade, Simon S., Longley, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429845/
https://www.ncbi.nlm.nih.gov/pubmed/32313199
http://dx.doi.org/10.1038/s41418-020-0539-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429845/
https://www.ncbi.nlm.nih.gov/pubmed/32313199
http://dx.doi.org/10.1038/s41418-020-0539-7

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