HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression

Liver dysfunction is strongly associated with poor survival of sepsis patients. Cytosolic lipopolysaccharide (LPS) sensing by Caspase-4/5/11 for pyroptosis activation is a major driver of the development of sepsis. Studies in macrophages and endothelial cells have demonstrated that LPS is inactivate...

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Detalles Bibliográficos
Autores principales: Liu, Jiali, Du, Shuya, Kong, Qiuyue, Zhang, Xiaojin, Jiang, Surong, Cao, Xiaofei, Li, Yuehua, Li, Chuanfu, Chen, Huaqun, Ding, Zhengnian, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429872/
https://www.ncbi.nlm.nih.gov/pubmed/32332915
http://dx.doi.org/10.1038/s41418-020-0536-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429872/
https://www.ncbi.nlm.nih.gov/pubmed/32332915
http://dx.doi.org/10.1038/s41418-020-0536-x

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