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Temporal Dynamics of GABA and Glx in the Visual Cortex

Magnetic resonance spectroscopy (MRS) can be used in vivo to quantify neurometabolite concentration and provide evidence for the involvement of different neurotransmitter systems (e.g., inhibitory and excitatory) in sensory and cognitive processes. The relatively low signal-to-noise ratio of MRS mea...

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Autor principal: Rideaux, Reuben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429906/
https://www.ncbi.nlm.nih.gov/pubmed/32571964
http://dx.doi.org/10.1523/ENEURO.0082-20.2020
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author Rideaux, Reuben
author_facet Rideaux, Reuben
author_sort Rideaux, Reuben
collection PubMed
description Magnetic resonance spectroscopy (MRS) can be used in vivo to quantify neurometabolite concentration and provide evidence for the involvement of different neurotransmitter systems (e.g., inhibitory and excitatory) in sensory and cognitive processes. The relatively low signal-to-noise ratio of MRS measurements has shaped the types of questions that it has been used to address. In particular, temporal resolution is often sacrificed in MRS studies to achieve a signal sufficient to produce a reliable estimate of neurometabolite concentration. Here we apply novel analyses with large datasets from human participants (both sexes) to reveal the dynamics of GABA(+) and Glx in visual cortex while participants are at rest (with eyes closed) and compare this with changes in posterior cingulate cortex from a previously collected dataset (under different conditions). We find that the dynamic concentration of GABA(+) and Glx in visual cortex drifts in opposite directions; that is, GABA(+) decreases while Glx increases over time. Further, we find that in visual, but not posterior cingulate cortex, the concentration of GABA(+) predicts that of Glx 120 s later, such that a change in GABA(+) is correlated with a subsequent opposite change in Glx. Together, these results expose novel temporal trends and interdependencies of primary neurotransmitters in visual cortex. More broadly, we demonstrate the feasibility of using MRS to investigate in vivo dynamic changes of neurometabolites.
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spelling pubmed-74299062020-08-17 Temporal Dynamics of GABA and Glx in the Visual Cortex Rideaux, Reuben eNeuro Research Article: New Research Magnetic resonance spectroscopy (MRS) can be used in vivo to quantify neurometabolite concentration and provide evidence for the involvement of different neurotransmitter systems (e.g., inhibitory and excitatory) in sensory and cognitive processes. The relatively low signal-to-noise ratio of MRS measurements has shaped the types of questions that it has been used to address. In particular, temporal resolution is often sacrificed in MRS studies to achieve a signal sufficient to produce a reliable estimate of neurometabolite concentration. Here we apply novel analyses with large datasets from human participants (both sexes) to reveal the dynamics of GABA(+) and Glx in visual cortex while participants are at rest (with eyes closed) and compare this with changes in posterior cingulate cortex from a previously collected dataset (under different conditions). We find that the dynamic concentration of GABA(+) and Glx in visual cortex drifts in opposite directions; that is, GABA(+) decreases while Glx increases over time. Further, we find that in visual, but not posterior cingulate cortex, the concentration of GABA(+) predicts that of Glx 120 s later, such that a change in GABA(+) is correlated with a subsequent opposite change in Glx. Together, these results expose novel temporal trends and interdependencies of primary neurotransmitters in visual cortex. More broadly, we demonstrate the feasibility of using MRS to investigate in vivo dynamic changes of neurometabolites. Society for Neuroscience 2020-07-09 /pmc/articles/PMC7429906/ /pubmed/32571964 http://dx.doi.org/10.1523/ENEURO.0082-20.2020 Text en Copyright © 2020 Rideaux http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Rideaux, Reuben
Temporal Dynamics of GABA and Glx in the Visual Cortex
title Temporal Dynamics of GABA and Glx in the Visual Cortex
title_full Temporal Dynamics of GABA and Glx in the Visual Cortex
title_fullStr Temporal Dynamics of GABA and Glx in the Visual Cortex
title_full_unstemmed Temporal Dynamics of GABA and Glx in the Visual Cortex
title_short Temporal Dynamics of GABA and Glx in the Visual Cortex
title_sort temporal dynamics of gaba and glx in the visual cortex
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429906/
https://www.ncbi.nlm.nih.gov/pubmed/32571964
http://dx.doi.org/10.1523/ENEURO.0082-20.2020
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