A scalable CRISPR/Cas9-based fluorescent reporter assay to study DNA double-strand break repair choice

Double-strand breaks (DSBs) are the most toxic type of DNA lesions. Cells repair these lesions using either end protection- or end resection-coupled mechanisms. To study DSB repair choice, we present the Color Assay Tracing-Repair (CAT-R) to simultaneously quantify DSB repair via end protection and...

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Detalles Bibliográficos
Autores principales: Roidos, Paris, Sungalee, Stephanie, Benfatto, Salvatore, Serçin, Özdemirhan, Stütz, Adrian M., Abdollahi, Amir, Mauer, Jan, Zenke, Frank T., Korbel, Jan O., Mardin, Balca R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429917/
https://www.ncbi.nlm.nih.gov/pubmed/32796846
http://dx.doi.org/10.1038/s41467-020-17962-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429917/
https://www.ncbi.nlm.nih.gov/pubmed/32796846
http://dx.doi.org/10.1038/s41467-020-17962-3

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