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Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition

Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. Th...

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Detalles Bibliográficos
Autores principales: Sturt, AS, Webb, EL, Francis, SC, Hayes, RJ, Bustinduy, AL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429987/
https://www.ncbi.nlm.nih.gov/pubmed/32416076
http://dx.doi.org/10.1016/j.actatropica.2020.105524
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author Sturt, AS
Webb, EL
Francis, SC
Hayes, RJ
Bustinduy, AL
author_facet Sturt, AS
Webb, EL
Francis, SC
Hayes, RJ
Bustinduy, AL
author_sort Sturt, AS
collection PubMed
description Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. There is cross-sectional evidence of increased HIV-1 prevalence in schistosomiasis-infected women, but a causal relationship between FGS and either HIV-1 acquisition or transmission has not been fully established. Beyond the pathognomonic breach in the cervicovaginal barrier caused by FGS, this narrative review explores potential mechanisms for a synergistic relationship between S. haematobium infection, FGS, and HIV-1 acquisition through vaginal inflammation and target cell recruitment.
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spelling pubmed-74299872020-09-01 Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition Sturt, AS Webb, EL Francis, SC Hayes, RJ Bustinduy, AL Acta Trop Article Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. There is cross-sectional evidence of increased HIV-1 prevalence in schistosomiasis-infected women, but a causal relationship between FGS and either HIV-1 acquisition or transmission has not been fully established. Beyond the pathognomonic breach in the cervicovaginal barrier caused by FGS, this narrative review explores potential mechanisms for a synergistic relationship between S. haematobium infection, FGS, and HIV-1 acquisition through vaginal inflammation and target cell recruitment. Elsevier 2020-09 /pmc/articles/PMC7429987/ /pubmed/32416076 http://dx.doi.org/10.1016/j.actatropica.2020.105524 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Sturt, AS
Webb, EL
Francis, SC
Hayes, RJ
Bustinduy, AL
Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition
title Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition
title_full Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition
title_fullStr Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition
title_full_unstemmed Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition
title_short Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition
title_sort beyond the barrier: female genital schistosomiasis as a potential risk factor for hiv-1 acquisition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429987/
https://www.ncbi.nlm.nih.gov/pubmed/32416076
http://dx.doi.org/10.1016/j.actatropica.2020.105524
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