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Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition
Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. Th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429987/ https://www.ncbi.nlm.nih.gov/pubmed/32416076 http://dx.doi.org/10.1016/j.actatropica.2020.105524 |
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author | Sturt, AS Webb, EL Francis, SC Hayes, RJ Bustinduy, AL |
author_facet | Sturt, AS Webb, EL Francis, SC Hayes, RJ Bustinduy, AL |
author_sort | Sturt, AS |
collection | PubMed |
description | Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. There is cross-sectional evidence of increased HIV-1 prevalence in schistosomiasis-infected women, but a causal relationship between FGS and either HIV-1 acquisition or transmission has not been fully established. Beyond the pathognomonic breach in the cervicovaginal barrier caused by FGS, this narrative review explores potential mechanisms for a synergistic relationship between S. haematobium infection, FGS, and HIV-1 acquisition through vaginal inflammation and target cell recruitment. |
format | Online Article Text |
id | pubmed-7429987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74299872020-09-01 Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition Sturt, AS Webb, EL Francis, SC Hayes, RJ Bustinduy, AL Acta Trop Article Female genital schistosomiasis (FGS) results from egg-deposition in the female reproductive tract primarily by the waterborne parasite Schistosoma (S.) haematobium, and less commonly by Schistosoma (S.) mansoni. FGS affects an estimated 20-56 million women worldwide, mostly in sub-Saharan Africa. There is cross-sectional evidence of increased HIV-1 prevalence in schistosomiasis-infected women, but a causal relationship between FGS and either HIV-1 acquisition or transmission has not been fully established. Beyond the pathognomonic breach in the cervicovaginal barrier caused by FGS, this narrative review explores potential mechanisms for a synergistic relationship between S. haematobium infection, FGS, and HIV-1 acquisition through vaginal inflammation and target cell recruitment. Elsevier 2020-09 /pmc/articles/PMC7429987/ /pubmed/32416076 http://dx.doi.org/10.1016/j.actatropica.2020.105524 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Sturt, AS Webb, EL Francis, SC Hayes, RJ Bustinduy, AL Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition |
title | Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition |
title_full | Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition |
title_fullStr | Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition |
title_full_unstemmed | Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition |
title_short | Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition |
title_sort | beyond the barrier: female genital schistosomiasis as a potential risk factor for hiv-1 acquisition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429987/ https://www.ncbi.nlm.nih.gov/pubmed/32416076 http://dx.doi.org/10.1016/j.actatropica.2020.105524 |
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