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Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality—a 10-year follow-up study
OBJECTIVE: To describe actual cardiovascular events over a decade in patients with diffuse idiopathic skeletal hyperostosis (DISH), without previously known CV diseases. METHODS: The medical records of patients with DISH and controls, beginning in 2006 (without known CV disease), were reviewed. Demo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430040/ https://www.ncbi.nlm.nih.gov/pubmed/32807215 http://dx.doi.org/10.1186/s13075-020-02278-w |
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author | Glick, Karina Novofastovski, Irina Schwartz, Naama Mader, Reuven |
author_facet | Glick, Karina Novofastovski, Irina Schwartz, Naama Mader, Reuven |
author_sort | Glick, Karina |
collection | PubMed |
description | OBJECTIVE: To describe actual cardiovascular events over a decade in patients with diffuse idiopathic skeletal hyperostosis (DISH), without previously known CV diseases. METHODS: The medical records of patients with DISH and controls, beginning in 2006 (without known CV disease), were reviewed. Demographic, constitutional, and laboratory data were collected. Comparison of CV events following 2006 was performed according to the outcome definitions set by the Framingham score 2: coronary event demonstrated by a coronary imaging modality, acute myocardial infarction (MI), coronary death, congestive heart failure with a reduced ejection fraction, and angina pectoris. RESULTS: Data were available for 45 patients with DISH and 47 controls without DISH from the original cohort (91.8% and 97.9% respectively). By the Framingham score, 28.6% (± 20.33) of the DISH patients were expected to be affected with CVD at 10 years of follow-up. We observed that nearly 39% of them developed CVD during that period (95% CI 23.8–53.5%). The incidence of MI over the 10-year period was significantly higher in the DISH group (P = 0.005). The DISH group had higher morbidity with a higher composite outcome of 38.8% vs 25.5% in the control cohort, and the number of non-elective hospital admissions per patient, despite neither reaching statistical significance. CONCLUSION: Our study showed that the Framingham score underestimates the real risk for developing CVD in patients with DISH, specifically the risk for MI. We propose more scrutiny is warranted in evaluating CV risk in these patients, more demanding treatment target goals should be established, and earlier and more aggressive medical interventions should be undertaken, particularly primary prevention. Larger prospective studies are needed to corroborate these findings. |
format | Online Article Text |
id | pubmed-7430040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74300402020-08-18 Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality—a 10-year follow-up study Glick, Karina Novofastovski, Irina Schwartz, Naama Mader, Reuven Arthritis Res Ther Research Article OBJECTIVE: To describe actual cardiovascular events over a decade in patients with diffuse idiopathic skeletal hyperostosis (DISH), without previously known CV diseases. METHODS: The medical records of patients with DISH and controls, beginning in 2006 (without known CV disease), were reviewed. Demographic, constitutional, and laboratory data were collected. Comparison of CV events following 2006 was performed according to the outcome definitions set by the Framingham score 2: coronary event demonstrated by a coronary imaging modality, acute myocardial infarction (MI), coronary death, congestive heart failure with a reduced ejection fraction, and angina pectoris. RESULTS: Data were available for 45 patients with DISH and 47 controls without DISH from the original cohort (91.8% and 97.9% respectively). By the Framingham score, 28.6% (± 20.33) of the DISH patients were expected to be affected with CVD at 10 years of follow-up. We observed that nearly 39% of them developed CVD during that period (95% CI 23.8–53.5%). The incidence of MI over the 10-year period was significantly higher in the DISH group (P = 0.005). The DISH group had higher morbidity with a higher composite outcome of 38.8% vs 25.5% in the control cohort, and the number of non-elective hospital admissions per patient, despite neither reaching statistical significance. CONCLUSION: Our study showed that the Framingham score underestimates the real risk for developing CVD in patients with DISH, specifically the risk for MI. We propose more scrutiny is warranted in evaluating CV risk in these patients, more demanding treatment target goals should be established, and earlier and more aggressive medical interventions should be undertaken, particularly primary prevention. Larger prospective studies are needed to corroborate these findings. BioMed Central 2020-08-17 2020 /pmc/articles/PMC7430040/ /pubmed/32807215 http://dx.doi.org/10.1186/s13075-020-02278-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Glick, Karina Novofastovski, Irina Schwartz, Naama Mader, Reuven Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality—a 10-year follow-up study |
title | Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality—a 10-year follow-up study |
title_full | Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality—a 10-year follow-up study |
title_fullStr | Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality—a 10-year follow-up study |
title_full_unstemmed | Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality—a 10-year follow-up study |
title_short | Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality—a 10-year follow-up study |
title_sort | cardiovascular disease in diffuse idiopathic skeletal hyperostosis (dish): from theory to reality—a 10-year follow-up study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430040/ https://www.ncbi.nlm.nih.gov/pubmed/32807215 http://dx.doi.org/10.1186/s13075-020-02278-w |
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