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De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report

BACKGROUND: Immunosuppression is essential after liver transplantation (LT). It, however, increases the risk for cancer. OBJECTIVE: To evaluate the prevalence and outcome of upper gastrointestinal (GI) tract cancer in LT patients and assess the perioperative risk of surgery for the upper GI malignan...

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Autores principales: Dobrindt, E. M., Biebl, M., Rademacher, S., Denecke, C., Andreou, A., Raakow, J., Kröll, D., Öllinger, R., Pratschke, J., Chopra, S. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Organ Transplantation Institute 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430062/
https://www.ncbi.nlm.nih.gov/pubmed/32832042
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author Dobrindt, E. M.
Biebl, M.
Rademacher, S.
Denecke, C.
Andreou, A.
Raakow, J.
Kröll, D.
Öllinger, R.
Pratschke, J.
Chopra, S. S.
author_facet Dobrindt, E. M.
Biebl, M.
Rademacher, S.
Denecke, C.
Andreou, A.
Raakow, J.
Kröll, D.
Öllinger, R.
Pratschke, J.
Chopra, S. S.
author_sort Dobrindt, E. M.
collection PubMed
description BACKGROUND: Immunosuppression is essential after liver transplantation (LT). It, however, increases the risk for cancer. OBJECTIVE: To evaluate the prevalence and outcome of upper gastrointestinal (GI) tract cancer in LT patients and assess the perioperative risk of surgery for the upper GI malignancies post-LT. METHODS: 2855 patients underwent LT at our clinic from 1988 to 2018. 20 patients developed upper GI cancer. Data were retrospectively extracted from our database. Analysis included patients’ specific data, tumor histopathology and stage, the treatment given and survival. RESULTS: 23 patients developed upper GI malignancies (2 gastric and 18 esophageal cancers; 3 excluded), translating to a incidence of 26.4 per 100,000 population per year. All patients were male. 80% showed alcohol-induced cirrhosis before LT. Most of the tumors were diagnosed at a stage ≥III. 70% underwent surgery and 78.6% developed postoperative complications. One-year-survival was 50%. Total survival rate was 28.6% with a median follow-up of 10 months (range: 0–184). CONCLUSION: Upper GI malignancies are more common after LT compared to the general population. Men after LT, due to alcohol-induced liver cirrhosis, are at a higher risk. Upper GI surgery after LT can be safe, but the severe risk for complications and a poor survival require strict indications.
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spelling pubmed-74300622020-08-20 De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report Dobrindt, E. M. Biebl, M. Rademacher, S. Denecke, C. Andreou, A. Raakow, J. Kröll, D. Öllinger, R. Pratschke, J. Chopra, S. S. Int J Organ Transplant Med Original Article BACKGROUND: Immunosuppression is essential after liver transplantation (LT). It, however, increases the risk for cancer. OBJECTIVE: To evaluate the prevalence and outcome of upper gastrointestinal (GI) tract cancer in LT patients and assess the perioperative risk of surgery for the upper GI malignancies post-LT. METHODS: 2855 patients underwent LT at our clinic from 1988 to 2018. 20 patients developed upper GI cancer. Data were retrospectively extracted from our database. Analysis included patients’ specific data, tumor histopathology and stage, the treatment given and survival. RESULTS: 23 patients developed upper GI malignancies (2 gastric and 18 esophageal cancers; 3 excluded), translating to a incidence of 26.4 per 100,000 population per year. All patients were male. 80% showed alcohol-induced cirrhosis before LT. Most of the tumors were diagnosed at a stage ≥III. 70% underwent surgery and 78.6% developed postoperative complications. One-year-survival was 50%. Total survival rate was 28.6% with a median follow-up of 10 months (range: 0–184). CONCLUSION: Upper GI malignancies are more common after LT compared to the general population. Men after LT, due to alcohol-induced liver cirrhosis, are at a higher risk. Upper GI surgery after LT can be safe, but the severe risk for complications and a poor survival require strict indications. Avicenna Organ Transplantation Institute 2020 /pmc/articles/PMC7430062/ /pubmed/32832042 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dobrindt, E. M.
Biebl, M.
Rademacher, S.
Denecke, C.
Andreou, A.
Raakow, J.
Kröll, D.
Öllinger, R.
Pratschke, J.
Chopra, S. S.
De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report
title De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report
title_full De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report
title_fullStr De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report
title_full_unstemmed De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report
title_short De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report
title_sort de-novo upper gastrointestinal tract cancer after liver transplantation: a demographic report
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430062/
https://www.ncbi.nlm.nih.gov/pubmed/32832042
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