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De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report
BACKGROUND: Immunosuppression is essential after liver transplantation (LT). It, however, increases the risk for cancer. OBJECTIVE: To evaluate the prevalence and outcome of upper gastrointestinal (GI) tract cancer in LT patients and assess the perioperative risk of surgery for the upper GI malignan...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Avicenna Organ Transplantation Institute
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430062/ https://www.ncbi.nlm.nih.gov/pubmed/32832042 |
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author | Dobrindt, E. M. Biebl, M. Rademacher, S. Denecke, C. Andreou, A. Raakow, J. Kröll, D. Öllinger, R. Pratschke, J. Chopra, S. S. |
author_facet | Dobrindt, E. M. Biebl, M. Rademacher, S. Denecke, C. Andreou, A. Raakow, J. Kröll, D. Öllinger, R. Pratschke, J. Chopra, S. S. |
author_sort | Dobrindt, E. M. |
collection | PubMed |
description | BACKGROUND: Immunosuppression is essential after liver transplantation (LT). It, however, increases the risk for cancer. OBJECTIVE: To evaluate the prevalence and outcome of upper gastrointestinal (GI) tract cancer in LT patients and assess the perioperative risk of surgery for the upper GI malignancies post-LT. METHODS: 2855 patients underwent LT at our clinic from 1988 to 2018. 20 patients developed upper GI cancer. Data were retrospectively extracted from our database. Analysis included patients’ specific data, tumor histopathology and stage, the treatment given and survival. RESULTS: 23 patients developed upper GI malignancies (2 gastric and 18 esophageal cancers; 3 excluded), translating to a incidence of 26.4 per 100,000 population per year. All patients were male. 80% showed alcohol-induced cirrhosis before LT. Most of the tumors were diagnosed at a stage ≥III. 70% underwent surgery and 78.6% developed postoperative complications. One-year-survival was 50%. Total survival rate was 28.6% with a median follow-up of 10 months (range: 0–184). CONCLUSION: Upper GI malignancies are more common after LT compared to the general population. Men after LT, due to alcohol-induced liver cirrhosis, are at a higher risk. Upper GI surgery after LT can be safe, but the severe risk for complications and a poor survival require strict indications. |
format | Online Article Text |
id | pubmed-7430062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Avicenna Organ Transplantation Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-74300622020-08-20 De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report Dobrindt, E. M. Biebl, M. Rademacher, S. Denecke, C. Andreou, A. Raakow, J. Kröll, D. Öllinger, R. Pratschke, J. Chopra, S. S. Int J Organ Transplant Med Original Article BACKGROUND: Immunosuppression is essential after liver transplantation (LT). It, however, increases the risk for cancer. OBJECTIVE: To evaluate the prevalence and outcome of upper gastrointestinal (GI) tract cancer in LT patients and assess the perioperative risk of surgery for the upper GI malignancies post-LT. METHODS: 2855 patients underwent LT at our clinic from 1988 to 2018. 20 patients developed upper GI cancer. Data were retrospectively extracted from our database. Analysis included patients’ specific data, tumor histopathology and stage, the treatment given and survival. RESULTS: 23 patients developed upper GI malignancies (2 gastric and 18 esophageal cancers; 3 excluded), translating to a incidence of 26.4 per 100,000 population per year. All patients were male. 80% showed alcohol-induced cirrhosis before LT. Most of the tumors were diagnosed at a stage ≥III. 70% underwent surgery and 78.6% developed postoperative complications. One-year-survival was 50%. Total survival rate was 28.6% with a median follow-up of 10 months (range: 0–184). CONCLUSION: Upper GI malignancies are more common after LT compared to the general population. Men after LT, due to alcohol-induced liver cirrhosis, are at a higher risk. Upper GI surgery after LT can be safe, but the severe risk for complications and a poor survival require strict indications. Avicenna Organ Transplantation Institute 2020 /pmc/articles/PMC7430062/ /pubmed/32832042 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dobrindt, E. M. Biebl, M. Rademacher, S. Denecke, C. Andreou, A. Raakow, J. Kröll, D. Öllinger, R. Pratschke, J. Chopra, S. S. De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report |
title |
De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report |
title_full |
De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report |
title_fullStr |
De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report |
title_full_unstemmed |
De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report |
title_short |
De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report |
title_sort | de-novo upper gastrointestinal tract cancer after liver transplantation: a demographic report |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430062/ https://www.ncbi.nlm.nih.gov/pubmed/32832042 |
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