A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy

Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by thrombotic m...

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Autores principales: Kusadasi, Nuray, Sikma, Maaike, Huisman, Albert, Westerink, Jan, Maas, Coen, Schutgens, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430228/
https://www.ncbi.nlm.nih.gov/pubmed/32885147
http://dx.doi.org/10.1097/HS9.0000000000000457
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author Kusadasi, Nuray
Sikma, Maaike
Huisman, Albert
Westerink, Jan
Maas, Coen
Schutgens, Roger
author_facet Kusadasi, Nuray
Sikma, Maaike
Huisman, Albert
Westerink, Jan
Maas, Coen
Schutgens, Roger
author_sort Kusadasi, Nuray
collection PubMed
description Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by thrombotic microangiopathy and endotheliitis. These microangiopathic changes cannot be classified as classical disseminated intravascular coagulation (DIC). In this short review we describe the interaction between coagulation and inflammation with focus on the possible mechanisms that might be involved in SARS-CoV-2 infection associated coagulopathy in the critically ill.
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spelling pubmed-74302282020-09-02 A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy Kusadasi, Nuray Sikma, Maaike Huisman, Albert Westerink, Jan Maas, Coen Schutgens, Roger Hemasphere Review Article Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by thrombotic microangiopathy and endotheliitis. These microangiopathic changes cannot be classified as classical disseminated intravascular coagulation (DIC). In this short review we describe the interaction between coagulation and inflammation with focus on the possible mechanisms that might be involved in SARS-CoV-2 infection associated coagulopathy in the critically ill. Wolters Kluwer Health 2020-08-10 /pmc/articles/PMC7430228/ /pubmed/32885147 http://dx.doi.org/10.1097/HS9.0000000000000457 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Review Article
Kusadasi, Nuray
Sikma, Maaike
Huisman, Albert
Westerink, Jan
Maas, Coen
Schutgens, Roger
A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_full A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_fullStr A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_full_unstemmed A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_short A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy
title_sort pathophysiological perspective on the sars-cov-2 coagulopathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430228/
https://www.ncbi.nlm.nih.gov/pubmed/32885147
http://dx.doi.org/10.1097/HS9.0000000000000457
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