Coronavirus 2019, Microthromboses, and Platelet Activating Factor

Recent articles have reported elevated markers of coagulation, endothelial injury, and microthromboses in lungs from deceased patients with coronavirus 2019 (COVID-19). Platelets are critical in the formation of thrombi, and their most potent trigger is platelet activating factor (PAF). PAF is produ...

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Autores principales: Theoharides, Theoharis C., Antonopoulou, Smaragdi, Demopoulos, Constantinos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430296/
https://www.ncbi.nlm.nih.gov/pubmed/32883529
http://dx.doi.org/10.1016/j.clinthera.2020.08.006
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author Theoharides, Theoharis C.
Antonopoulou, Smaragdi
Demopoulos, Constantinos A.
author_facet Theoharides, Theoharis C.
Antonopoulou, Smaragdi
Demopoulos, Constantinos A.
author_sort Theoharides, Theoharis C.
collection PubMed
description Recent articles have reported elevated markers of coagulation, endothelial injury, and microthromboses in lungs from deceased patients with coronavirus 2019 (COVID-19). Platelets are critical in the formation of thrombi, and their most potent trigger is platelet activating factor (PAF). PAF is produced by cells involved in host defense, and its biological actions bear similarities with COVID-19 disease manifestations, including pulmonary microthromboses and inflammation, possibly via activation of mast cells. The histamine(1) receptor antagonist rupatadine was developed to have anti-PAF activity and inhibits activation of human mast cells in response to PAF. Rupatadine could be repurposed for COVID-19 prophylaxis.
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spelling pubmed-74302962020-08-18 Coronavirus 2019, Microthromboses, and Platelet Activating Factor Theoharides, Theoharis C. Antonopoulou, Smaragdi Demopoulos, Constantinos A. Clin Ther Commentary Recent articles have reported elevated markers of coagulation, endothelial injury, and microthromboses in lungs from deceased patients with coronavirus 2019 (COVID-19). Platelets are critical in the formation of thrombi, and their most potent trigger is platelet activating factor (PAF). PAF is produced by cells involved in host defense, and its biological actions bear similarities with COVID-19 disease manifestations, including pulmonary microthromboses and inflammation, possibly via activation of mast cells. The histamine(1) receptor antagonist rupatadine was developed to have anti-PAF activity and inhibits activation of human mast cells in response to PAF. Rupatadine could be repurposed for COVID-19 prophylaxis. Elsevier Inc. 2020-10 2020-08-17 /pmc/articles/PMC7430296/ /pubmed/32883529 http://dx.doi.org/10.1016/j.clinthera.2020.08.006 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Commentary
Theoharides, Theoharis C.
Antonopoulou, Smaragdi
Demopoulos, Constantinos A.
Coronavirus 2019, Microthromboses, and Platelet Activating Factor
title Coronavirus 2019, Microthromboses, and Platelet Activating Factor
title_full Coronavirus 2019, Microthromboses, and Platelet Activating Factor
title_fullStr Coronavirus 2019, Microthromboses, and Platelet Activating Factor
title_full_unstemmed Coronavirus 2019, Microthromboses, and Platelet Activating Factor
title_short Coronavirus 2019, Microthromboses, and Platelet Activating Factor
title_sort coronavirus 2019, microthromboses, and platelet activating factor
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430296/
https://www.ncbi.nlm.nih.gov/pubmed/32883529
http://dx.doi.org/10.1016/j.clinthera.2020.08.006
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