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Systemic AAV10.COMP-Ang1 rescues renal glomeruli and pancreatic islets in type 2 diabetic mice

INTRODUCTION: Diabetic hyperglycemia causes progressive and generalized damage to the microvasculature. In renal glomeruli, this results in the loss of podocytes with consequent loss of constitutive angiopoietin-1 (Ang1) signaling, which is required for stability of the glomerular endothelium. Repea...

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Detalles Bibliográficos
Autores principales:	Tian, Mi, Carroll, Lara S, Tang, Li, Uehara, Hironori, Westenfelder, Christof, Ambati, Balamurali K, Huang, Yufeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Pathophysiology/Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430492/ https://www.ncbi.nlm.nih.gov/pubmed/32792355 http://dx.doi.org/10.1136/bmjdrc-2019-000882

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