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Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

RATIONALE: SARS-CoV-2 entry into host cells is facilitated by endogenous and exogenous proteases that proteolytically activate the spike glycoprotein and antiproteases inhibiting this process. Understanding the key actors in viral entry is crucial for advancing knowledge of virus tropism, pathogenes...

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Detalles Bibliográficos
Autores principales:	Stevens, Christian S, Oguntuyo, Kasopefoluwa Y, Kowdle, Shreyas, Brambilla, Luca, Haas, Griffin, Gowlikar, Aditya, Siddiquey, Mohammed NA, Schilke, Robert M, Woolard, Matthew D, Zhang, Hongbo, Acklin, Joshua A, Ikegame, Satoshi, Huang, Chuan-Tien, Lim, Jean K, Cross, Robert W, Geisbert, Thomas W, Ivanov, Stanimir S, Kamil, Jeremy P, Lee, Benhur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430570/ https://www.ncbi.nlm.nih.gov/pubmed/32817940 http://dx.doi.org/10.1101/2020.08.14.248880

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