Cargando…

RADX condenses single-stranded DNA to antagonize RAD51 loading

RADX is a mammalian single-stranded DNA-binding protein that stabilizes telomeres and stalled replication forks. Cellular biology studies have shown that the balance between RADX and Replication Protein A (RPA) is critical for DNA replication integrity. RADX is also a negative regulator of RAD51-med...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hongshan, Schaub, Jeffrey M, Finkelstein, Ilya J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430644/ https://www.ncbi.nlm.nih.gov/pubmed/32621611 http://dx.doi.org/10.1093/nar/gkaa559

Ejemplares similares

Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
por: Schaub, Jeffrey M, et al.
Publicado: (2022)

Dual roles of yeast Rad51 N-terminal domain in repairing DNA double-strand breaks
por: Woo, Tai-Ting, et al.
Publicado: (2020)

FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end
por: Sato, Koichi, et al.
Publicado: (2016)

RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function
por: So, Ayeong, et al.
Publicado: (2022)

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament
por: Ma, Chu Jian, et al.
Publicado: (2017)

GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination
por: Takizawa, Yoshimasa, et al.
Publicado: (2010)

Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase
por: Mohan, Monisha, et al.
Publicado: (2019)

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
por: Liu, Wenpeng, et al.
Publicado: (2023)

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction
por: Subramanyam, Shyamal, et al.
Publicado: (2013)

DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange
por: Ishida, Takako, et al.
Publicado: (2009)

The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55–Rad57 to mediate error-free recombination
por: Godin, Stephen, et al.
Publicado: (2013)

RAD51 interconnects between DNA replication, DNA repair and immunity
por: Bhattacharya, Souparno, et al.
Publicado: (2017)

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption
por: Colavito, Sierra, et al.
Publicado: (2009)

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
por: Guh, Chia-Lun, et al.
Publicado: (2023)

Ca(2+) improves organization of single-stranded DNA bases in human Rad51 filament, explaining stimulatory effect on gene recombination
por: Fornander, Louise H., et al.
Publicado: (2012)

Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament
por: Fornander, Louise H., et al.
Publicado: (2014)

An archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadA
por: Haseltine, Cynthia A., et al.
Publicado: (2009)

Strand annealing and motor driven activities of SMARCAL1 and ZRANB3 are stimulated by RAD51 and the paralog complex
por: Halder, Swagata, et al.
Publicado: (2022)

Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair
por: Manthey, Glenn M., et al.
Publicado: (2017)

Caffeine inhibits gene conversion by displacing Rad51 from ssDNA
por: Tsabar, Michael, et al.
Publicado: (2015)

Cooperation of RAD51 and RAD54 in regression of a model replication fork
por: Bugreev, Dmitry V., et al.
Publicado: (2011)

Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase δ in Rad52-mediated direct-repeat recombination
por: Cerqueira, Paula G, et al.
Publicado: (2023)

Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair
por: Sánchez, Humberto, et al.
Publicado: (2017)

LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA
por: Shen, Liping, et al.
Publicado: (2018)

Inter-subunit interactions that coordinate Rad51's activities
por: Grigorescu, Arabela A., et al.
Publicado: (2009)

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
por: Mladenov, Emil, et al.
Publicado: (2020)

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells
por: Mason, Jennifer M., et al.
Publicado: (2015)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2015)

ATP-dependent nucleosome unwrapping catalyzed by human RAD51
por: North, Justin A., et al.
Publicado: (2013)

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes
por: Grimme, Jill M., et al.
Publicado: (2010)

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity
por: Chatterjee, Gouri, et al.
Publicado: (2016)

Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency
por: Di Domenico, Enea Gino, et al.
Publicado: (2013)

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2015)

RAD51 and RTEL1 compensate telomere loss in the absence of telomerase
por: Olivier, Margaux, et al.
Publicado: (2018)

Microcephaly family protein MCPH1 stabilizes RAD51 filaments
por: Chang, Hao-Yen, et al.
Publicado: (2020)

TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair
por: Hariharasudhan, Gurusamy, et al.
Publicado: (2022)

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
por: Britton, Sébastien, et al.
Publicado: (2020)

Detection of novel recombinases in bacteriophage genomes unveils Rad52, Rad51 and Gp2.5 remote homologs
por: Lopes, Anne, et al.
Publicado: (2010)

Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation
por: Onaka, Atsushi T., et al.
Publicado: (2016)

Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2
por: Malik, Punjab S., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_bov46psetberjas01ikbakgu5k