Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae

Circular DNA can arise from all parts of eukaryotic chromosomes. In yeast, circular ribosomal DNA (rDNA) accumulates dramatically as cells age, however little is known about the accumulation of other chromosome-derived circles or the contribution of such circles to genetic variation in aged cells. W...

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Detalles Bibliográficos
Autores principales: Prada-Luengo, Iñigo, Møller, Henrik D, Henriksen, Rasmus A, Gao, Qian, Larsen, Camilla Eggert, Alizadeh, Sefa, Maretty, Lasse, Houseley, Jonathan, Regenberg, Birgitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430651/
https://www.ncbi.nlm.nih.gov/pubmed/32609810
http://dx.doi.org/10.1093/nar/gkaa545

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