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Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi ca...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430703/ https://www.ncbi.nlm.nih.gov/pubmed/32804950 http://dx.doi.org/10.1371/journal.pntd.0008530 |
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author | Im, Justin Islam, Md. Taufiqul Kim, Deok Ryun Ahmmed, Faisal Chon, Yun Zaman, K. Khan, Ashraful Islam Ali, Mohammad Sur, Dipika Kanungo, Suman Dutta, Shanta Bhattacharya, Sujit K. Dougan, Gordon Holt, Kathryn E. Marks, Florian Kim, Jerome H. Qadri, Firdausi Clemens, John D. |
author_facet | Im, Justin Islam, Md. Taufiqul Kim, Deok Ryun Ahmmed, Faisal Chon, Yun Zaman, K. Khan, Ashraful Islam Ali, Mohammad Sur, Dipika Kanungo, Suman Dutta, Shanta Bhattacharya, Sujit K. Dougan, Gordon Holt, Kathryn E. Marks, Florian Kim, Jerome H. Qadri, Firdausi Clemens, John D. |
author_sort | Im, Justin |
collection | PubMed |
description | We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysaccharide typhoid vaccine in Kolkata, India. A population of 70,566 individuals, of whom 37,673 were vaccinated with one dose of either Vi vaccine or a control (Hepatitis A) vaccine, were observed for four years. Surveillance detected 315 first typhoid visits, among whom 4 developed subsequent typhoid, 3 due to reinfection, defined using genomic criteria and corresponding to -124% (95% CI: -599, 28) protection by the initial illness. Point estimates of protection conferred by an initial illness were negative or negligible in both vaccinated and non-vaccinated subjects, though confidence intervals around the point estimates were wide. These data provide little support for a protective immunizing effect of clinically treated typhoid illness, though modest levels of protection cannot be excluded. |
format | Online Article Text |
id | pubmed-7430703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74307032020-08-20 Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata Im, Justin Islam, Md. Taufiqul Kim, Deok Ryun Ahmmed, Faisal Chon, Yun Zaman, K. Khan, Ashraful Islam Ali, Mohammad Sur, Dipika Kanungo, Suman Dutta, Shanta Bhattacharya, Sujit K. Dougan, Gordon Holt, Kathryn E. Marks, Florian Kim, Jerome H. Qadri, Firdausi Clemens, John D. PLoS Negl Trop Dis Research Article We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysaccharide typhoid vaccine in Kolkata, India. A population of 70,566 individuals, of whom 37,673 were vaccinated with one dose of either Vi vaccine or a control (Hepatitis A) vaccine, were observed for four years. Surveillance detected 315 first typhoid visits, among whom 4 developed subsequent typhoid, 3 due to reinfection, defined using genomic criteria and corresponding to -124% (95% CI: -599, 28) protection by the initial illness. Point estimates of protection conferred by an initial illness were negative or negligible in both vaccinated and non-vaccinated subjects, though confidence intervals around the point estimates were wide. These data provide little support for a protective immunizing effect of clinically treated typhoid illness, though modest levels of protection cannot be excluded. Public Library of Science 2020-08-17 /pmc/articles/PMC7430703/ /pubmed/32804950 http://dx.doi.org/10.1371/journal.pntd.0008530 Text en © 2020 Im et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Im, Justin Islam, Md. Taufiqul Kim, Deok Ryun Ahmmed, Faisal Chon, Yun Zaman, K. Khan, Ashraful Islam Ali, Mohammad Sur, Dipika Kanungo, Suman Dutta, Shanta Bhattacharya, Sujit K. Dougan, Gordon Holt, Kathryn E. Marks, Florian Kim, Jerome H. Qadri, Firdausi Clemens, John D. Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata |
title | Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata |
title_full | Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata |
title_fullStr | Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata |
title_full_unstemmed | Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata |
title_short | Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata |
title_sort | protection conferred by typhoid fever against recurrent typhoid fever in urban kolkata |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430703/ https://www.ncbi.nlm.nih.gov/pubmed/32804950 http://dx.doi.org/10.1371/journal.pntd.0008530 |
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