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Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata

We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi ca...

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Autores principales: Im, Justin, Islam, Md. Taufiqul, Kim, Deok Ryun, Ahmmed, Faisal, Chon, Yun, Zaman, K., Khan, Ashraful Islam, Ali, Mohammad, Sur, Dipika, Kanungo, Suman, Dutta, Shanta, Bhattacharya, Sujit K., Dougan, Gordon, Holt, Kathryn E., Marks, Florian, Kim, Jerome H., Qadri, Firdausi, Clemens, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430703/
https://www.ncbi.nlm.nih.gov/pubmed/32804950
http://dx.doi.org/10.1371/journal.pntd.0008530
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author Im, Justin
Islam, Md. Taufiqul
Kim, Deok Ryun
Ahmmed, Faisal
Chon, Yun
Zaman, K.
Khan, Ashraful Islam
Ali, Mohammad
Sur, Dipika
Kanungo, Suman
Dutta, Shanta
Bhattacharya, Sujit K.
Dougan, Gordon
Holt, Kathryn E.
Marks, Florian
Kim, Jerome H.
Qadri, Firdausi
Clemens, John D.
author_facet Im, Justin
Islam, Md. Taufiqul
Kim, Deok Ryun
Ahmmed, Faisal
Chon, Yun
Zaman, K.
Khan, Ashraful Islam
Ali, Mohammad
Sur, Dipika
Kanungo, Suman
Dutta, Shanta
Bhattacharya, Sujit K.
Dougan, Gordon
Holt, Kathryn E.
Marks, Florian
Kim, Jerome H.
Qadri, Firdausi
Clemens, John D.
author_sort Im, Justin
collection PubMed
description We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysaccharide typhoid vaccine in Kolkata, India. A population of 70,566 individuals, of whom 37,673 were vaccinated with one dose of either Vi vaccine or a control (Hepatitis A) vaccine, were observed for four years. Surveillance detected 315 first typhoid visits, among whom 4 developed subsequent typhoid, 3 due to reinfection, defined using genomic criteria and corresponding to -124% (95% CI: -599, 28) protection by the initial illness. Point estimates of protection conferred by an initial illness were negative or negligible in both vaccinated and non-vaccinated subjects, though confidence intervals around the point estimates were wide. These data provide little support for a protective immunizing effect of clinically treated typhoid illness, though modest levels of protection cannot be excluded.
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spelling pubmed-74307032020-08-20 Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata Im, Justin Islam, Md. Taufiqul Kim, Deok Ryun Ahmmed, Faisal Chon, Yun Zaman, K. Khan, Ashraful Islam Ali, Mohammad Sur, Dipika Kanungo, Suman Dutta, Shanta Bhattacharya, Sujit K. Dougan, Gordon Holt, Kathryn E. Marks, Florian Kim, Jerome H. Qadri, Firdausi Clemens, John D. PLoS Negl Trop Dis Research Article We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysaccharide typhoid vaccine in Kolkata, India. A population of 70,566 individuals, of whom 37,673 were vaccinated with one dose of either Vi vaccine or a control (Hepatitis A) vaccine, were observed for four years. Surveillance detected 315 first typhoid visits, among whom 4 developed subsequent typhoid, 3 due to reinfection, defined using genomic criteria and corresponding to -124% (95% CI: -599, 28) protection by the initial illness. Point estimates of protection conferred by an initial illness were negative or negligible in both vaccinated and non-vaccinated subjects, though confidence intervals around the point estimates were wide. These data provide little support for a protective immunizing effect of clinically treated typhoid illness, though modest levels of protection cannot be excluded. Public Library of Science 2020-08-17 /pmc/articles/PMC7430703/ /pubmed/32804950 http://dx.doi.org/10.1371/journal.pntd.0008530 Text en © 2020 Im et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Im, Justin
Islam, Md. Taufiqul
Kim, Deok Ryun
Ahmmed, Faisal
Chon, Yun
Zaman, K.
Khan, Ashraful Islam
Ali, Mohammad
Sur, Dipika
Kanungo, Suman
Dutta, Shanta
Bhattacharya, Sujit K.
Dougan, Gordon
Holt, Kathryn E.
Marks, Florian
Kim, Jerome H.
Qadri, Firdausi
Clemens, John D.
Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
title Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
title_full Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
title_fullStr Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
title_full_unstemmed Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
title_short Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
title_sort protection conferred by typhoid fever against recurrent typhoid fever in urban kolkata
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430703/
https://www.ncbi.nlm.nih.gov/pubmed/32804950
http://dx.doi.org/10.1371/journal.pntd.0008530
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