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Delayed Thrombotic Complications in a Thrombotic Thrombocytopenic Purpura Patient Treated With Caplacizumab
Thrombotic thrombocytopenic purpura (TTP) is a rare and unpredictable disease with a high mortality rate (90%) if untreated. It results from systemic microvascular thrombosis and leads to profound thrombocytopenia, hemolytic anemia and organ failure of varying severity. However, macrovascular thromb...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430863/ https://www.ncbi.nlm.nih.gov/pubmed/32855757 http://dx.doi.org/10.14740/jh614 |
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author | Cilla, Nicolas Dallemagne, Julie Vanhove, Marie Stordeur, Patrick Motte, Serge De Wilde, Virginie |
author_facet | Cilla, Nicolas Dallemagne, Julie Vanhove, Marie Stordeur, Patrick Motte, Serge De Wilde, Virginie |
author_sort | Cilla, Nicolas |
collection | PubMed |
description | Thrombotic thrombocytopenic purpura (TTP) is a rare and unpredictable disease with a high mortality rate (90%) if untreated. It results from systemic microvascular thrombosis and leads to profound thrombocytopenia, hemolytic anemia and organ failure of varying severity. However, macrovascular thrombosis has been described in very rare cases. Caplacizumab has emerged as a promising new drug for the management of TTP. We report the case of a patient with idiopathic refractory TTP treated with caplacizumab who developed thrombotic complications upon discontinuation of treatment. |
format | Online Article Text |
id | pubmed-7430863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74308632020-09-01 Delayed Thrombotic Complications in a Thrombotic Thrombocytopenic Purpura Patient Treated With Caplacizumab Cilla, Nicolas Dallemagne, Julie Vanhove, Marie Stordeur, Patrick Motte, Serge De Wilde, Virginie J Hematol Case Report Thrombotic thrombocytopenic purpura (TTP) is a rare and unpredictable disease with a high mortality rate (90%) if untreated. It results from systemic microvascular thrombosis and leads to profound thrombocytopenia, hemolytic anemia and organ failure of varying severity. However, macrovascular thrombosis has been described in very rare cases. Caplacizumab has emerged as a promising new drug for the management of TTP. We report the case of a patient with idiopathic refractory TTP treated with caplacizumab who developed thrombotic complications upon discontinuation of treatment. Elmer Press 2020-09 2020-08-14 /pmc/articles/PMC7430863/ /pubmed/32855757 http://dx.doi.org/10.14740/jh614 Text en Copyright 2020, Cilla et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Cilla, Nicolas Dallemagne, Julie Vanhove, Marie Stordeur, Patrick Motte, Serge De Wilde, Virginie Delayed Thrombotic Complications in a Thrombotic Thrombocytopenic Purpura Patient Treated With Caplacizumab |
title | Delayed Thrombotic Complications in a Thrombotic Thrombocytopenic Purpura Patient Treated With Caplacizumab |
title_full | Delayed Thrombotic Complications in a Thrombotic Thrombocytopenic Purpura Patient Treated With Caplacizumab |
title_fullStr | Delayed Thrombotic Complications in a Thrombotic Thrombocytopenic Purpura Patient Treated With Caplacizumab |
title_full_unstemmed | Delayed Thrombotic Complications in a Thrombotic Thrombocytopenic Purpura Patient Treated With Caplacizumab |
title_short | Delayed Thrombotic Complications in a Thrombotic Thrombocytopenic Purpura Patient Treated With Caplacizumab |
title_sort | delayed thrombotic complications in a thrombotic thrombocytopenic purpura patient treated with caplacizumab |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430863/ https://www.ncbi.nlm.nih.gov/pubmed/32855757 http://dx.doi.org/10.14740/jh614 |
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