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Game theoretic centrality: a novel approach to prioritize disease candidate genes by combining biological networks with the Shapley value
BACKGROUND: Complex human health conditions with etiological heterogeneity like Autism Spectrum Disorder (ASD) often pose a challenge for traditional genome-wide association study approaches in defining a clear genotype to phenotype model. Coalitional game theory (CGT) is an exciting method that can...
Autores principales: | Sun, Min Woo, Moretti, Stefano, Paskov, Kelley M., Stockham, Nate T., Varma, Maya, Chrisman, Brianna S., Washington, Peter Y., Jung, Jae-Yoon, Wall, Dennis P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430867/ https://www.ncbi.nlm.nih.gov/pubmed/32787845 http://dx.doi.org/10.1186/s12859-020-03693-1 |
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