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Cardiotoxicity by Anthracycline Regimen Chemotherapy Prolonged T Peak to T End Interval

BACKGROUND: Myocardial necrosis may occur due to anthracycline (doxorubicin/adriamycin) chemotherapy usage. Furthermore, myocardial necrosis can affect the heterogeneity of heart conduction system and lead to repolarization abnormalities. The aim of this study was to investigate the effect of cardio...

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Autores principales: Iqbal, Mohammad, Victory, Viky, Astuti, Astri, Febrianora, Mega, Karwiky, Giky, Achmad, Chaerul, Akbar, Mohammad Rizki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430896/
https://www.ncbi.nlm.nih.gov/pubmed/32849965
http://dx.doi.org/10.14740/cr1052
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author Iqbal, Mohammad
Victory, Viky
Astuti, Astri
Febrianora, Mega
Karwiky, Giky
Achmad, Chaerul
Akbar, Mohammad Rizki
author_facet Iqbal, Mohammad
Victory, Viky
Astuti, Astri
Febrianora, Mega
Karwiky, Giky
Achmad, Chaerul
Akbar, Mohammad Rizki
author_sort Iqbal, Mohammad
collection PubMed
description BACKGROUND: Myocardial necrosis may occur due to anthracycline (doxorubicin/adriamycin) chemotherapy usage. Furthermore, myocardial necrosis can affect the heterogeneity of heart conduction system and lead to repolarization abnormalities. The aim of this study was to investigate the effect of cardiotoxicity caused by anthracycline to repolarization abnormalities measured by T peak to T end (TpTe) interval. METHODS: This was a single center prospective cohort study with linear regression from October 2018 to May 2019. The subjects of the study were breast cancer patients after completing administration of chemotherapy with fluorouracil, adriamycin and cyclophosphamide (FAC) regimen (containing anthracycline) for 6 months. Myocardial necrosis was assessed by high sensitive (hs)-troponin I, and the heterogeneity of repolarization was measured by TpTe interval. RESULTS: This study involved 25 breast cancer patients after chemotherapy in the 6-month FAC regimen. The mean age is 46 ± 7 years, and the cumulative dose of anthracycline is 591 ± 52 mg/m(2). The mean level of hs-troponin I is 90.5 ± 44.7 ng/L and the TpTe interval is 108.2 ± 10 ms. The results of linear regression analysis showed a positive correlation between hs-troponin I and TpTe interval (r: 0.421, P: 0.036) after controlling for one confounding variable (cumulative dose of anthracycline). CONCLUSIONS: Cardiotoxicity caused by accumulative dose of anthracycline may lead to myocardial necrosis which was shown by elevated hs-troponin I levels. This process may lead to heterogeneity conduction system that affect the repolarization phase of cardiac cycle which was shown by increased TpTe interval.
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spelling pubmed-74308962020-08-25 Cardiotoxicity by Anthracycline Regimen Chemotherapy Prolonged T Peak to T End Interval Iqbal, Mohammad Victory, Viky Astuti, Astri Febrianora, Mega Karwiky, Giky Achmad, Chaerul Akbar, Mohammad Rizki Cardiol Res Original Article BACKGROUND: Myocardial necrosis may occur due to anthracycline (doxorubicin/adriamycin) chemotherapy usage. Furthermore, myocardial necrosis can affect the heterogeneity of heart conduction system and lead to repolarization abnormalities. The aim of this study was to investigate the effect of cardiotoxicity caused by anthracycline to repolarization abnormalities measured by T peak to T end (TpTe) interval. METHODS: This was a single center prospective cohort study with linear regression from October 2018 to May 2019. The subjects of the study were breast cancer patients after completing administration of chemotherapy with fluorouracil, adriamycin and cyclophosphamide (FAC) regimen (containing anthracycline) for 6 months. Myocardial necrosis was assessed by high sensitive (hs)-troponin I, and the heterogeneity of repolarization was measured by TpTe interval. RESULTS: This study involved 25 breast cancer patients after chemotherapy in the 6-month FAC regimen. The mean age is 46 ± 7 years, and the cumulative dose of anthracycline is 591 ± 52 mg/m(2). The mean level of hs-troponin I is 90.5 ± 44.7 ng/L and the TpTe interval is 108.2 ± 10 ms. The results of linear regression analysis showed a positive correlation between hs-troponin I and TpTe interval (r: 0.421, P: 0.036) after controlling for one confounding variable (cumulative dose of anthracycline). CONCLUSIONS: Cardiotoxicity caused by accumulative dose of anthracycline may lead to myocardial necrosis which was shown by elevated hs-troponin I levels. This process may lead to heterogeneity conduction system that affect the repolarization phase of cardiac cycle which was shown by increased TpTe interval. Elmer Press 2020-10 2020-08-01 /pmc/articles/PMC7430896/ /pubmed/32849965 http://dx.doi.org/10.14740/cr1052 Text en Copyright 2020, Iqbal et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Iqbal, Mohammad
Victory, Viky
Astuti, Astri
Febrianora, Mega
Karwiky, Giky
Achmad, Chaerul
Akbar, Mohammad Rizki
Cardiotoxicity by Anthracycline Regimen Chemotherapy Prolonged T Peak to T End Interval
title Cardiotoxicity by Anthracycline Regimen Chemotherapy Prolonged T Peak to T End Interval
title_full Cardiotoxicity by Anthracycline Regimen Chemotherapy Prolonged T Peak to T End Interval
title_fullStr Cardiotoxicity by Anthracycline Regimen Chemotherapy Prolonged T Peak to T End Interval
title_full_unstemmed Cardiotoxicity by Anthracycline Regimen Chemotherapy Prolonged T Peak to T End Interval
title_short Cardiotoxicity by Anthracycline Regimen Chemotherapy Prolonged T Peak to T End Interval
title_sort cardiotoxicity by anthracycline regimen chemotherapy prolonged t peak to t end interval
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430896/
https://www.ncbi.nlm.nih.gov/pubmed/32849965
http://dx.doi.org/10.14740/cr1052
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