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A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption(1,2). There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for...

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Autores principales: Gordon, David E., Jang, Gwendolyn M., Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M., O’Meara, Matthew J., Rezelj, Veronica V., Guo, Jeffrey Z., Swaney, Danielle L., Tummino, Tia A., Huettenhain, Ruth, Kaake, Robyn M., Richards, Alicia L., Tutuncuoglu, Beril, Foussard, Helene, Batra, Jyoti, Haas, Kelsey, Modak, Maya, Kim, Minkyu, Haas, Paige, Polacco, Benjamin J., Braberg, Hannes, Fabius, Jacqueline M., Eckhardt, Manon, Soucheray, Margaret, Bennett, Melanie J., Cakir, Merve, McGregor, Michael J., Li, Qiongyu, Meyer, Bjoern, Roesch, Ferdinand, Vallet, Thomas, Kain, Alice Mac, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T., Melnyk, James E., Chorba, John S., Lou, Kevin, Dai, Shizhong A., Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Lyu, Jiankun, Mathy, Christopher J.P., Perica, Tina, Pilla, Kala B., Ganesan, Sai J., Saltzberg, Daniel J., Rakesh, Ramachandran, Liu, Xi, Rosenthal, Sara B., Calviello, Lorenzo, Venkataramanan, Srivats, Liboy-Lugo, Jose, Lin, Yizhu, Huang, Xi-Ping, Liu, YongFeng, Wankowicz, Stephanie A., Bohn, Markus, Safari, Maliheh, Ugur, Fatima S., Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Shengjuler, Djoshkun, Fletcher, Sabrina J, O’Neal, Michael C., Cai, Yiming, C.J.Chang, Jason, Broadhurst, David J., Klippsten, Saker, Sharp, Phillip P., Wenzell, Nicole A., Kuzuoglu, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Young, Janet M., Cavero, Devin A., Hiatt, Joseph, Roth, Theodore L., Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M., Frankel, Alan D., Rosenberg, Oren S., Verba, Kliment A, Agard, David A., Ott, Melanie, Emerman, Michael, Jura, Natalia, von Zastrow, Mark, Verdin, Eric, Ashworth, Alan, Schwartz, Olivier, d’Enfert, Christophe, Mukherjee, Shaeri, Jacobson, Matt, Malik, Harmit S., Fujimori, Danica G., Ideker, Trey, Craik, Charles S., Floor, Stephen N., Fraser, James S., Gross, John D., Sali, Andrej, Roth, Bryan L., Ruggero, Davide, Taunton, Jack, Kortemme, Tanja, Beltrao, Pedro, Vignuzzi, Marco, García-Sastre, Adolfo, Shokat, Kevan M., Shoichet, Brian K., Krogan, Nevan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431030/
https://www.ncbi.nlm.nih.gov/pubmed/32353859
http://dx.doi.org/10.1038/s41586-020-2286-9