Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil

BACKGROUND: The efficacy of acetylcholinesterase inhibitors (AChE-I) might depend on blood concentration. While rivastigmine metabolism is independent of the cytochrome P450 system, its isoenzymes, especially CYP2D6, metabolize donepezil. CYP2D6 polymorphisms can cause altered enzyme activity result...

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Detalles Bibliográficos
Autores principales: Ortner, Marion, Stange, Marion, Schneider, Heike, Schröder, Charlotte, Buerger, Katharina, Müller, Claudia, Müller-Sarnowski, Felix, Diehl-Schmid, Janine, Förstl, Hans, Grimmer, Timo, Steimer, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431170/
https://www.ncbi.nlm.nih.gov/pubmed/32848364
http://dx.doi.org/10.2147/DDDT.S247259

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