Massive Acetaminophen Overdose

The authors present a case of a fatal intentional acetaminophen (APAP) overdose and remind the physician how ubiquitous the drug is. This case presentation highlights the clinical presentation and treatment options for APAP overdose in unresponsive patients. In cases of massive APAP overdose (> 3...

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Detalles Bibliográficos
Autores principales: Stead, Thor S, Jeong, Jae Yun, Ganti, Latha, Rubero, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Emergency Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431296/
https://www.ncbi.nlm.nih.gov/pubmed/32821608
http://dx.doi.org/10.7759/cureus.9262
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author Stead, Thor S
Jeong, Jae Yun
Ganti, Latha
Rubero, Jose
author_facet Stead, Thor S
Jeong, Jae Yun
Ganti, Latha
Rubero, Jose
author_sort Stead, Thor S
collection PubMed
description The authors present a case of a fatal intentional acetaminophen (APAP) overdose and remind the physician how ubiquitous the drug is. This case presentation highlights the clinical presentation and treatment options for APAP overdose in unresponsive patients. In cases of massive APAP overdose (> 300 µg/ml plasma at four hours post-ingestion), prompt administration of N-acetylcysteine (NAC) and early hemodialysis are indicated.
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spelling pubmed-74312962020-08-18 Massive Acetaminophen Overdose Stead, Thor S Jeong, Jae Yun Ganti, Latha Rubero, Jose Cureus Emergency Medicine The authors present a case of a fatal intentional acetaminophen (APAP) overdose and remind the physician how ubiquitous the drug is. This case presentation highlights the clinical presentation and treatment options for APAP overdose in unresponsive patients. In cases of massive APAP overdose (> 300 µg/ml plasma at four hours post-ingestion), prompt administration of N-acetylcysteine (NAC) and early hemodialysis are indicated. Cureus 2020-07-18 /pmc/articles/PMC7431296/ /pubmed/32821608 http://dx.doi.org/10.7759/cureus.9262 Text en Copyright © 2020, Stead et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Stead, Thor S
Jeong, Jae Yun
Ganti, Latha
Rubero, Jose
Massive Acetaminophen Overdose
title Massive Acetaminophen Overdose
title_full Massive Acetaminophen Overdose
title_fullStr Massive Acetaminophen Overdose
title_full_unstemmed Massive Acetaminophen Overdose
title_short Massive Acetaminophen Overdose
title_sort massive acetaminophen overdose
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431296/
https://www.ncbi.nlm.nih.gov/pubmed/32821608
http://dx.doi.org/10.7759/cureus.9262
work_keys_str_mv AT steadthors massiveacetaminophenoverdose
AT jeongjaeyun massiveacetaminophenoverdose
AT gantilatha massiveacetaminophenoverdose
AT ruberojose massiveacetaminophenoverdose

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