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The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications
During the period of pregnancy, several processes and physiological adaptations occur in the body and metabolism of pregnant woman. These physiological adaptations in pregnant woman end up leading to a suppression in immune system favoring obstetric complications to the mother, fetus and placental t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431318/ https://www.ncbi.nlm.nih.gov/pubmed/32862059 http://dx.doi.org/10.1016/j.placenta.2020.08.005 |
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author | Pereira, Kelle Velasques Giacomeli, Renata Gomes de Gomes, Marcelo Haas, Sandra Elisa |
author_facet | Pereira, Kelle Velasques Giacomeli, Renata Gomes de Gomes, Marcelo Haas, Sandra Elisa |
author_sort | Pereira, Kelle Velasques |
collection | PubMed |
description | During the period of pregnancy, several processes and physiological adaptations occur in the body and metabolism of pregnant woman. These physiological adaptations in pregnant woman end up leading to a suppression in immune system favoring obstetric complications to the mother, fetus and placental tissue. An effective pharmacological therapy for these complications is still a challenge, since some drugs during pregnancy can have deleterious and teratogenic effects. An emerging alternative to pharmacological therapy during pregnancy is drugs encapsulated in nanoparticles (NP), recent area called nano-obstetrics. NP have the advantage of drug targeting and reduction of side effects. Then, maternal, placental or fetal uptake can be expected, depending on the characteristics of NP. Inorganic NP, crossing placental barrier effectively, but have several nanotoxicological effects. While organic NP appear to have a better targeting capacity and have few toxicological effects, but the studies are still scarce. Thus, in this review, were examined questions related to use and impact of physicochemical aspects of inorganic and organic NP during pregnancy. |
format | Online Article Text |
id | pubmed-7431318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74313182020-08-18 The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications Pereira, Kelle Velasques Giacomeli, Renata Gomes de Gomes, Marcelo Haas, Sandra Elisa Placenta Classics Revisited During the period of pregnancy, several processes and physiological adaptations occur in the body and metabolism of pregnant woman. These physiological adaptations in pregnant woman end up leading to a suppression in immune system favoring obstetric complications to the mother, fetus and placental tissue. An effective pharmacological therapy for these complications is still a challenge, since some drugs during pregnancy can have deleterious and teratogenic effects. An emerging alternative to pharmacological therapy during pregnancy is drugs encapsulated in nanoparticles (NP), recent area called nano-obstetrics. NP have the advantage of drug targeting and reduction of side effects. Then, maternal, placental or fetal uptake can be expected, depending on the characteristics of NP. Inorganic NP, crossing placental barrier effectively, but have several nanotoxicological effects. While organic NP appear to have a better targeting capacity and have few toxicological effects, but the studies are still scarce. Thus, in this review, were examined questions related to use and impact of physicochemical aspects of inorganic and organic NP during pregnancy. Published by Elsevier Ltd. 2020-10 2020-08-18 /pmc/articles/PMC7431318/ /pubmed/32862059 http://dx.doi.org/10.1016/j.placenta.2020.08.005 Text en © 2020 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Classics Revisited Pereira, Kelle Velasques Giacomeli, Renata Gomes de Gomes, Marcelo Haas, Sandra Elisa The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications |
title | The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications |
title_full | The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications |
title_fullStr | The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications |
title_full_unstemmed | The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications |
title_short | The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications |
title_sort | challenge of using nanotherapy during pregnancy: technological aspects and biomedical implications |
topic | Classics Revisited |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431318/ https://www.ncbi.nlm.nih.gov/pubmed/32862059 http://dx.doi.org/10.1016/j.placenta.2020.08.005 |
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