2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

Under hypoxic conditions, nitroimidazoles can replace oxygen as electron acceptors, thereby enhancing the effects of radiation on malignant cells. These compounds also accumulate in hypoxic cells, where they can act as cytotoxins or imaging agents. However, whether these effects apply to cancer stem...

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Detalles Bibliográficos
Autores principales: Koike, Naoyoshi, Kota, Ryuichi, Naito, Yoshiko, Hayakawa, Noriyo, Matsuura, Tomomi, Hishiki, Takako, Onishi, Nobuyuki, Fukada, Junichi, Suematsu, Makoto, Shigematsu, Naoyuki, Saya, Hideyuki, Sampetrean, Oltea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431527/
https://www.ncbi.nlm.nih.gov/pubmed/32807853
http://dx.doi.org/10.1038/s42003-020-01165-z

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