High levels of ubidecarenone (oxidized CoQ(10)) delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells

Metabolic reprogramming in cancer cells, vs. non-cancer cells, elevates levels of reactive oxygen species (ROS) leading to higher oxidative stress. The elevated ROS levels suggest a vulnerability to excess prooxidant loads leading to selective cell death, a therapeutically exploitable difference. Co...

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Detalles Bibliográficos
Autores principales: Sun, Jiaxin, Patel, Chirag B., Jang, Taichang, Merchant, Milton, Chen, Chen, Kazerounian, Shiva, Diers, Anne R., Kiebish, Michael A., Vishnudas, Vivek K., Gesta, Stephane, Sarangarajan, Rangaprasad, Narain, Niven R., Nagpal, Seema, Recht, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431533/
https://www.ncbi.nlm.nih.gov/pubmed/32807842
http://dx.doi.org/10.1038/s41598-020-70969-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431533/
https://www.ncbi.nlm.nih.gov/pubmed/32807842
http://dx.doi.org/10.1038/s41598-020-70969-0

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