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Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases

Respiratory protection is key in infection prevention of airborne diseases, as highlighted by the COVID-19 pandemic for instance. Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration efficiency improvements limited by difficulty in breathing, and no safe reusabili...

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Autores principales: Rubino, Ilaria, Oh, Euna, Han, Sumin, Kaleem, Sana, Hornig, Alex, Lee, Su-Hwa, Kang, Hae-Ji, Lee, Dong-Hun, Chu, Ki-Back, Kumaran, Surjith, Armstrong, Sarah, Lalani, Romani, Choudhry, Shivanjali, Kim, Chun Il, Quan, Fu-Shi, Jeon, Byeonghwa, Choi, Hyo-Jick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431535/
https://www.ncbi.nlm.nih.gov/pubmed/32807805
http://dx.doi.org/10.1038/s41598-020-70623-9
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author Rubino, Ilaria
Oh, Euna
Han, Sumin
Kaleem, Sana
Hornig, Alex
Lee, Su-Hwa
Kang, Hae-Ji
Lee, Dong-Hun
Chu, Ki-Back
Kumaran, Surjith
Armstrong, Sarah
Lalani, Romani
Choudhry, Shivanjali
Kim, Chun Il
Quan, Fu-Shi
Jeon, Byeonghwa
Choi, Hyo-Jick
author_facet Rubino, Ilaria
Oh, Euna
Han, Sumin
Kaleem, Sana
Hornig, Alex
Lee, Su-Hwa
Kang, Hae-Ji
Lee, Dong-Hun
Chu, Ki-Back
Kumaran, Surjith
Armstrong, Sarah
Lalani, Romani
Choudhry, Shivanjali
Kim, Chun Il
Quan, Fu-Shi
Jeon, Byeonghwa
Choi, Hyo-Jick
author_sort Rubino, Ilaria
collection PubMed
description Respiratory protection is key in infection prevention of airborne diseases, as highlighted by the COVID-19 pandemic for instance. Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration efficiency improvements limited by difficulty in breathing, and no safe reusability), which have yet to be addressed in a single device. Here, we report the development of a filter overcoming the major technical challenges of respiratory protective devices. Large-pore membranes, offering high breathability but low bacteria capture, were functionalized to have a uniform salt layer on the fibers. The salt-functionalized membranes achieved high filtration efficiency as opposed to the bare membrane, with differences of up to 48%, while maintaining high breathability (> 60% increase compared to commercial surgical masks even for the thickest salt filters tested). The salt-functionalized filters quickly killed Gram-positive and Gram-negative bacteria aerosols in vitro, with CFU reductions observed as early as within 5 min, and in vivo by causing structural damage due to salt recrystallization. The salt coatings retained the pathogen inactivation capability at harsh environmental conditions (37 °C and a relative humidity of 70%, 80% and 90%). Combination of these properties in one filter will lead to the production of an effective device, comprehensibly mitigating infection transmission globally.
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spelling pubmed-74315352020-08-18 Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases Rubino, Ilaria Oh, Euna Han, Sumin Kaleem, Sana Hornig, Alex Lee, Su-Hwa Kang, Hae-Ji Lee, Dong-Hun Chu, Ki-Back Kumaran, Surjith Armstrong, Sarah Lalani, Romani Choudhry, Shivanjali Kim, Chun Il Quan, Fu-Shi Jeon, Byeonghwa Choi, Hyo-Jick Sci Rep Article Respiratory protection is key in infection prevention of airborne diseases, as highlighted by the COVID-19 pandemic for instance. Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration efficiency improvements limited by difficulty in breathing, and no safe reusability), which have yet to be addressed in a single device. Here, we report the development of a filter overcoming the major technical challenges of respiratory protective devices. Large-pore membranes, offering high breathability but low bacteria capture, were functionalized to have a uniform salt layer on the fibers. The salt-functionalized membranes achieved high filtration efficiency as opposed to the bare membrane, with differences of up to 48%, while maintaining high breathability (> 60% increase compared to commercial surgical masks even for the thickest salt filters tested). The salt-functionalized filters quickly killed Gram-positive and Gram-negative bacteria aerosols in vitro, with CFU reductions observed as early as within 5 min, and in vivo by causing structural damage due to salt recrystallization. The salt coatings retained the pathogen inactivation capability at harsh environmental conditions (37 °C and a relative humidity of 70%, 80% and 90%). Combination of these properties in one filter will lead to the production of an effective device, comprehensibly mitigating infection transmission globally. Nature Publishing Group UK 2020-08-17 /pmc/articles/PMC7431535/ /pubmed/32807805 http://dx.doi.org/10.1038/s41598-020-70623-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rubino, Ilaria
Oh, Euna
Han, Sumin
Kaleem, Sana
Hornig, Alex
Lee, Su-Hwa
Kang, Hae-Ji
Lee, Dong-Hun
Chu, Ki-Back
Kumaran, Surjith
Armstrong, Sarah
Lalani, Romani
Choudhry, Shivanjali
Kim, Chun Il
Quan, Fu-Shi
Jeon, Byeonghwa
Choi, Hyo-Jick
Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_full Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_fullStr Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_full_unstemmed Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_short Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
title_sort salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431535/
https://www.ncbi.nlm.nih.gov/pubmed/32807805
http://dx.doi.org/10.1038/s41598-020-70623-9
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