Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

Vasoactive intestinal polypeptide receptor (VIP1R) is a widely expressed class B G protein-coupled receptor and a drug target for the treatment of neuronal, metabolic, and inflammatory diseases. However, our understanding of its mechanism of action and the potential of drug discovery targeting this...

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Detalles Bibliográficos
Autores principales: Duan, Jia, Shen, Dan-dan, Zhou, X. Edward, Bi, Peng, Liu, Qiu-feng, Tan, Yang-xia, Zhuang, You-wen, Zhang, Hui-bing, Xu, Pei-yu, Huang, Si-Jie, Ma, Shan-shan, He, Xin-heng, Melcher, Karsten, Zhang, Yan, Xu, H. Eric, Jiang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431577/
https://www.ncbi.nlm.nih.gov/pubmed/32807782
http://dx.doi.org/10.1038/s41467-020-17933-8

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