Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. Here, we describe the concept of augmented synthetic lethality (ASL): depletion of a third gene product enhances a pre-existing synthetic lethal combination. W...

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Detalles Bibliográficos
Autores principales: Kong, Yi Wen, Dreaden, Erik C., Morandell, Sandra, Zhou, Wen, Dhara, Sanjeev S., Sriram, Ganapathy, Lam, Fred C., Patterson, Jesse C., Quadir, Mohiuddin, Dinh, Anh, Shopsowitz, Kevin E., Varmeh, Shohreh, Yilmaz, Ömer H., Lippard, Stephen J., Reinhardt, H. Christian, Hemann, Michael T., Hammond, Paula T., Yaffe, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431578/
https://www.ncbi.nlm.nih.gov/pubmed/32807787
http://dx.doi.org/10.1038/s41467-020-17958-z

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