A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD(+)

Cytidine deaminase (CDA) deficiency causes pyrimidine pool disequilibrium. We previously reported that the excess cellular dC and dCTP resulting from CDA deficiency jeopardizes genome stability, decreasing basal poly(ADP-ribose) polymerase 1 (PARP-1) activity and increasing ultrafine anaphase bridge...

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Detalles Bibliográficos
Autores principales: Silveira, Sandra Cunha, Buhagiar-Labarchède, Géraldine, Onclercq-Delic, Rosine, Gemble, Simon, Bou Samra, Elias, Mameri, Hamza, Duchambon, Patricia, Machon, Christelle, Guitton, Jérôme, Amor-Guéret, Mounira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431583/
https://www.ncbi.nlm.nih.gov/pubmed/32807821
http://dx.doi.org/10.1038/s41598-020-70874-6

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