Vitamin K2 Can Rescue the Dexamethasone-Induced Downregulation of Osteoblast Autophagy and Mitophagy Thereby Restoring Osteoblast Function In Vitro and In Vivo

Chronic long-term glucocorticoids (GC) use is associated with glucocorticoid-induced osteoporosis (GIOP) by inhibiting the survival and impairing the functions of osteoblasts. Autophagy and mitophagy play key roles in osteoblast differentiation, mineralization and survival, and mounting evidence hav...

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Detalles Bibliográficos
Autores principales: Chen, Liang, Shi, Xiang, Weng, She-Ji, Xie, Jun, Tang, Jia-Hao, Yan, De-Yi, Wang, Bing-Zhang, Xie, Zhong-Jie, Wu, Zong-Yi, Yang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431688/
https://www.ncbi.nlm.nih.gov/pubmed/32848799
http://dx.doi.org/10.3389/fphar.2020.01209

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