Uveitis-induced Refractory Ocular Hypotony Managed with High-dose Latanoprost

PURPOSE: To report a case of refractory ocular hypotony due to chronic Behcet's disease with good response to high-dose topical latanoprost. CASE REPORT: We present a 26-year-old man with a known history of Behcet's disease who developed decreasing vision and severe ocular hypotony that was refractory to multiple treatment modalities including subtenon triamcinolone acetonide, ibopamine, pars plana vitrectomy, and silicone oil injection. We decided to try high-dose topical latanoprost for the management of ocular hypotony based on recent reports. After six months, intraocular pressure (IOP) increased by 5 mm Hg, became stable at 7 mm Hg, and remained unchanged at month 24. CONCLUSION: High-dose topical latanoprost could lead to significant increase in IOP in uveitis-induced refractory ocular hypotony.