Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline

In somatic cells/tissues, methylation of ribosomal DNA (rDNA) increases with age and age‐related pathologies, which has a direct impact on the regulation of nucleolar activity and cellular metabolism. Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit inc...

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Detalles Bibliográficos
Autores principales: Potabattula, Ramya, Zacchini, Federica, Ptak, Grazyna Ewa, Dittrich, Marcus, Müller, Tobias, El Hajj, Nady, Hahn, Thomas, Drummer, Charis, Behr, Rüdiger, Lucas‐Hahn, Andrea, Niemann, Heiner, Schorsch, Martin, Haaf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431825/
https://www.ncbi.nlm.nih.gov/pubmed/32608562
http://dx.doi.org/10.1111/acel.13181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431825/
https://www.ncbi.nlm.nih.gov/pubmed/32608562
http://dx.doi.org/10.1111/acel.13181

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