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Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging

During aging, some individuals are resilient to the decline of cognitive functions whereas others are vulnerable. These inter‐individual differences in memory abilities have been associated with differences in the rate of hippocampal neurogenesis measured in elderlies. Whether the maintenance of the...

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Autores principales: Montaron, Marie‐Françoise, Charrier, Vanessa, Blin, Nicolas, Garcia, Pierre, Abrous, Djoher Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431828/
https://www.ncbi.nlm.nih.gov/pubmed/32599664
http://dx.doi.org/10.1111/acel.13161
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author Montaron, Marie‐Françoise
Charrier, Vanessa
Blin, Nicolas
Garcia, Pierre
Abrous, Djoher Nora
author_facet Montaron, Marie‐Françoise
Charrier, Vanessa
Blin, Nicolas
Garcia, Pierre
Abrous, Djoher Nora
author_sort Montaron, Marie‐Françoise
collection PubMed
description During aging, some individuals are resilient to the decline of cognitive functions whereas others are vulnerable. These inter‐individual differences in memory abilities have been associated with differences in the rate of hippocampal neurogenesis measured in elderlies. Whether the maintenance of the functionality of neurons generated throughout adult life is linked to resilience to cognitive aging remains completely unexplored. Using the immediate early gene Zif268, we analyzed the activation of dentate granule neurons born in adult (3‐month‐old), middle‐aged (12‐month‐old), or senescent (18‐month‐old) rats (n = 96) in response to learning when animals reached 21 months of age. The activation of neurons born during the developmental period was also examined. We show that adult‐born neurons can survive up to 19 months and that neurons generated 4, 10, or 19 months before learning, but not developmentally born neurons, are activated in senescent rats with good learning abilities. In contrast, aged rats with bad learning abilities do not exhibit activity‐dependent regulation of newborn cells, whatever their birthdate. In conclusion, we propose that resilience to cognitive aging is associated with responsiveness of neurons born during adult life. These data add to our current knowledge by showing that the aging of memory abilities stems not only from the number but also from the responsiveness of adult‐born neurons.
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spelling pubmed-74318282020-08-20 Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging Montaron, Marie‐Françoise Charrier, Vanessa Blin, Nicolas Garcia, Pierre Abrous, Djoher Nora Aging Cell Original Articles During aging, some individuals are resilient to the decline of cognitive functions whereas others are vulnerable. These inter‐individual differences in memory abilities have been associated with differences in the rate of hippocampal neurogenesis measured in elderlies. Whether the maintenance of the functionality of neurons generated throughout adult life is linked to resilience to cognitive aging remains completely unexplored. Using the immediate early gene Zif268, we analyzed the activation of dentate granule neurons born in adult (3‐month‐old), middle‐aged (12‐month‐old), or senescent (18‐month‐old) rats (n = 96) in response to learning when animals reached 21 months of age. The activation of neurons born during the developmental period was also examined. We show that adult‐born neurons can survive up to 19 months and that neurons generated 4, 10, or 19 months before learning, but not developmentally born neurons, are activated in senescent rats with good learning abilities. In contrast, aged rats with bad learning abilities do not exhibit activity‐dependent regulation of newborn cells, whatever their birthdate. In conclusion, we propose that resilience to cognitive aging is associated with responsiveness of neurons born during adult life. These data add to our current knowledge by showing that the aging of memory abilities stems not only from the number but also from the responsiveness of adult‐born neurons. John Wiley and Sons Inc. 2020-06-29 2020-08 /pmc/articles/PMC7431828/ /pubmed/32599664 http://dx.doi.org/10.1111/acel.13161 Text en © 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Montaron, Marie‐Françoise
Charrier, Vanessa
Blin, Nicolas
Garcia, Pierre
Abrous, Djoher Nora
Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging
title Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging
title_full Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging
title_fullStr Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging
title_full_unstemmed Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging
title_short Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging
title_sort responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431828/
https://www.ncbi.nlm.nih.gov/pubmed/32599664
http://dx.doi.org/10.1111/acel.13161
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