T-cells produce acidic niches in lymph nodes to suppress their own effector functions

The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells. We hypothesize that this is a physiological process in immune regulation, and that it occurs within lymph nodes (LNs), which are likely acidic because of low convective flow and high glucose metabolism. Here w...

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Detalles Bibliográficos
Autores principales: Wu, Hao, Estrella, Veronica, Beatty, Matthew, Abrahams, Dominique, El-Kenawi, Asmaa, Russell, Shonagh, Ibrahim-Hashim, Arig, Longo, Dario Livio, Reshetnyak, Yana K., Moshnikova, Anna, Andreev, Oleg A., Luddy, Kimberly, Damaghi, Mehdi, Kodumudi, Krithika, Pillai, Smitha R., Enriquez-Navas, Pedro, Pilon-Thomas, Shari, Swietach, Pawel, Gillies, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431837/
https://www.ncbi.nlm.nih.gov/pubmed/32807791
http://dx.doi.org/10.1038/s41467-020-17756-7

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